ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
bartleby

Videos

Textbook Question
Book Icon
Chapter 19, Problem 27P

The Drosophila mutant screen shown on the right-hand side of Fig. 19.18 was limited; it could identify mutations only in maternal effect genes whose functions were not required in female tissues other than the eggs they produced.

a. What aspect of the screen imposed this limitation?
b. How could you determine if any of the mutations identified are in genes required in males?
c. Why was the Balancer chromosome needed in the screen?
Blurred answer
Students have asked these similar questions
In this module, you have learned about the use of balancer chromosomes (such as TM2 and TM6C in the below crossing scheme) for isolating Drosophila mutants during EMS mutagenesis. Please inspect the following crossing scheme and choose which of the following statements is correct.     A. TM6C is preferable over TM2 when performing mutagenesis   B. EMS induces chromosomal inversion   C. A balancer chromosome helps to isolate on which chromosome the mutant is located   D. Following the above crossing scheme all flies with no TM2 or TM6C markers are mutants
Drosophila females homozygous for loss-of-functionmutations in the gene aubergine are sterile. RNA-Seqexperiments show that in the ovaries of these females,the levels of RNAs for many kinds of transposable elements are more than 10× higher than in wild-type ovaries. The aubergine gene encodes a Piwi-family protein.a. Why do you think these females are sterile?b. Piwi proteins interact with piRNAs that are transcribed from piRNA gene clusters. Given that thelevels of many kinds of TEs are elevated in mutantovaries, what kinds of DNA sequences do youthink are located in these clusters?c. Many investigators think of piRNAs as a kind ofdefensive mechanism that protects organisms fromthe effects of new transposable elements that mightbe introduced into genomes, for example fromother species. Explain
Mutations in the HPRT1 gene in humans result in atleast two clinical syndromes. Consult OMIM (www.omim.org) by querying HPRT1; you will only needto look briefly at the top three hits (files #300322,300323, and 308000).a. What is the full name of the HPRT1 enzyme?b. On which chromosome is the HPRT1 gene located?c. Mutations in HPRT1 are associated with two different syndromes. What are these syndromes? Foreach, answer the following questions: (i) What arethe symptoms associated with the syndrome? (ii) Isthe mutant allele that causes the syndrome dominant, recessive, codominant, or incompletely dominant with respect to the normal allele, or do specialconditions apply? (iii) Is the syndrome associatedwith a loss-of-function or a gain-of-function disease allele? (iv) Does the syndrome display allelicheterogeneity? (v) Does the syndrome display locus heterogeneity? (Note: You do not need to understand everything in the OMIM entries to answerthese questions.)
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Embryology | Fertilization, Cleavage, Blastulation; Author: Ninja Nerd;https://www.youtube.com/watch?v=8-KF0rnhKTU;License: Standard YouTube License, CC-BY