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ORGANIC CHEMISTRY-W/S.G+SOLN.MANUAL
8th Edition
ISBN: 9780134595450
Author: Bruice
Publisher: PEARSON
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Textbook Question
Chapter 21, Problem 63P
Identify the location and type of charge on the hexapeptide Lys-Ser-Asp-Cys-His-Tyr at each of the following pH values:
a. pH = 1
b. pH = 5
c. pH = 7
d. pH =12
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Students have asked these similar questions
What is the net charge on the tripeptide His-Glu-Lys at pH 7? The table below gives the pKa's of the ionizable groups on the free amino acids
Free AA
pKa of COO-
pKa of NH3+
His
1.8
9.2
Glutamate
2.2
9.7
Lysine
2.2
9.1
a. -2
b. -1
c. 0
d. +1
e. +2
What is the net charge of the tetrapeptide
C-R-Y-K at pH 11.5
QUESTION 31
Copy of
The following reaction scheme shows the states of the amino acid hisitdine. Histidine has three pKa's - 2, 6 and 9.2.
Which form of Histidine predominates at pH of 5?
"H3N-CH-C-O°
CH2
H2N-CH-C-O-
*H3N-CH-C–OH
CH2
*H3N-CH-C-o-
CH2
CH2
*HN
+HN
NH
-NH
NH
-NH
A
C
O A. A
O B. B
O C. C
D. D
E. The answer cannot be determined with information given.
Chapter 21 Solutions
ORGANIC CHEMISTRY-W/S.G+SOLN.MANUAL
Ch. 21.1 - a. Explain why, when the imidazole ring of...Ch. 21.2 - a. Which isomer(R)-alanine or (S)-alanineis...Ch. 21.2 - Prob. 4PCh. 21.3 - Prob. 5PCh. 21.3 - Prob. 6PCh. 21.3 - Draw the predominant form for glutamate in a...Ch. 21.3 - a. Why is the pKa of the glutamate side chain...Ch. 21.4 - Calculate the pI of each of the following amino...Ch. 21.4 - a. Which amino acid has the lowest pI value? b....Ch. 21.4 - Prob. 12P
Ch. 21.4 - Prob. 13PCh. 21.4 - Explain why the pI of lysine is the average of the...Ch. 21.5 - What aldehyde is formed when valine is treated...Ch. 21.5 - Prob. 16PCh. 21.5 - Prob. 17PCh. 21.5 - Prob. 18PCh. 21.5 - Prob. 19PCh. 21.6 - Why is excess ammonia used in the preceding...Ch. 21.6 - Prob. 21PCh. 21.6 - What amino acid is formed using the...Ch. 21.6 - Prob. 23PCh. 21.6 - What amino acid is formed when the aldehyde used...Ch. 21.7 - Esterase is an enzyme that catalyzes the...Ch. 21.8 - Draw the tetrapeptide Ala-Thr-Asp-Asn and indicate...Ch. 21.8 - Draw the resonance contributors of the peptide...Ch. 21.8 - Which bonds in the backbone of a peptide can...Ch. 21.9 - An opioid pentapeptide has the following...Ch. 21.9 - What is the configuration about each of the...Ch. 21.9 - Glutathione is a tripeptide whose function is to...Ch. 21.10 - What dipeptides would be formed by heating a...Ch. 21.10 - Suppose you are trying to synthesize the dipeptide...Ch. 21.10 - Show the steps in the synthesis of the...Ch. 21.10 - a. Calculate the overall yield of bradykinin when...Ch. 21.11 - Show the steps in the synthesis of the...Ch. 21.13 - Prob. 37PCh. 21.13 - In determining the primary structure of insulin,...Ch. 21.13 - A decapeptide undergoes partial hydrolysis to give...Ch. 21.13 - Explain why cyanogen bromide does not cleave on...Ch. 21.13 - Indicate the peptides produced from cleavage by...Ch. 21.14 - Prob. 43PCh. 21.14 - Three peptides were obtained from a trypsin...Ch. 21.14 - Prob. 45PCh. 21.15 - How would a protein that resides in the nonpolar...Ch. 21.16 - a. Which would have the greatest percentage of...Ch. 21.17 - When apples that have been cut are exposed to...Ch. 21 - Glycine has pK2 values of 2.34 and 9.60. At what...Ch. 21 - Prob. 50PCh. 21 - A titration curve is a plot of the pH of a...Ch. 21 - Prob. 52PCh. 21 - Aspartame (its structure is on page 1007) has a pl...Ch. 21 - Draw the form of aspartate that predominates at...Ch. 21 - Show how phenylalanine can be prepared by...Ch. 21 - A professor was preparing a manuscript for...Ch. 21 - What aldehydes are formed when the following amino...Ch. 21 - Prob. 58PCh. 21 - Determine the amino acid sequence of a polypeptide...Ch. 21 - Prob. 60PCh. 21 - Prob. 61PCh. 21 - Which is the more effective buffer at...Ch. 21 - Identify the location and type of charge on the...Ch. 21 - Draw the product obtained when a lysine side chain...Ch. 21 - After the polypeptide shown below was treated with...Ch. 21 - Treatment of a polypeptide with 2-mercaptoethanol...Ch. 21 - Show how aspartame can be synthesized using DCCD.Ch. 21 - -Amino acids can be prepared by treating an...Ch. 21 - Reaction of a polypeptide with carboxypeptidase A...Ch. 21 - a. How many different octapeptides can be made...Ch. 21 - Glycine has pKa values of 2.3 and 9.6. Do you...Ch. 21 - A mixture of 15 amino acids gave the fingerprint...Ch. 21 - Write the mechanism for the reaction of an amino...Ch. 21 - Prob. 74PCh. 21 - Show how valine can be prepared by a. a...Ch. 21 - The primary structure of -endorphin, a peptide...Ch. 21 - A chemist wanted to test his hypothesis that the...Ch. 21 - Propose a mechanism for the rearrangement of the...Ch. 21 - A normal polypeptide and a mutant of the...Ch. 21 - Determine the amino acid sequence of a polypeptide...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Similar questions
- The isoelectric point of the tripeptide Gly-Ser-Ala occurs at a value below pH 7 at pH 7 at a value above pH 7 C neverarrow_forwardChemistry 11. What is the net charge on the peptide Ala-Arg-His-Ser-Lys-Glu-Thr-Pro-Tyr-Gln-Asn-Arg-His-Ile at pH 7.0? Use the pK, values in Table 3.1. A) +2.0 B)-2.0 C) +1.0 D) -1.0 E) 0.0arrow_forward3. Which of the following amino acids would be negative at pH = 7? A. P B. V C. E D. K 4. What is the expected pl of Arginine? A. pH = 2 B. pH = 7 C. pH = 10 D. pH = 14arrow_forward
- What is the charge of the Peptide DMQK at pH=7 ? A) -2 B) 0 C) -1 D) +2arrow_forwardThe isoelectric point of the tripeptide Gly-Ser-Ala occurs at a value below pH 7 сссс at pH 7 at a value above pH 7 neverarrow_forward12. Draw the products of the acid-catalyzed hydrolysis of the peptide shown below: H₂N. OH OH HCI H₂Oarrow_forward
- What is the pI for the polypeptide ALRHEN? Use pKa of 8 for the N-terminus and 4 for the C-terminus.arrow_forwardIdentify the location and type of charge on the hexapeptide Lys-Ser-Asp-Cys-His-Tyr at each of the following pH values: a. pH = 1 b. pH = 5 c. pH = 7 d. pH = 12arrow_forward3. Draw the tripeptide Alanine-Cysteine-Serine (R1 = CH3, R2 = CH2SH, R3 = CH2OH) under the following pH conditions and list the net charge on the protein. A. pH= 1 Net charge? B. pH=7 Net charge? C. pH=12 Net charge?arrow_forward
- The octapeptide angiotensin II has the sequence Asp-Arg-Val-Tyr-Ile-His-Pro- Phe. What fragments would result if angiotensin II were cleaved with trypsin? With chymotrypsin?arrow_forwardEstimate the pI of each tripeptide in Problem 27.46. Draw a structural formula of these tripeptides. Mark each peptide bond, the N-terminal amino acid, and the C-terminal amino acid. (a) Phe-Val-Asn (b) Leu-Val-Glnarrow_forwardMost amino acids have isoelectric points between 5.0 and 6.0, but the isoelectric point of lysine is 9.7. Explain why lysine has such a high value for its isoelectric point.arrow_forward
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