The most reasonable structure for compound 3 in the given reaction sequence is to be chosen. Concept introduction: Substituents attached to an aromatic ring promote metalation and control its regioselectivity. Metalation usually takes place at the carbon atom ortho to the substituent. Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case. Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

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Answer 1

Question

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

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Answer 2

Question

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

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Answer 3

Question

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

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Answer 4

Question

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

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Answer 5

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

Answer 6

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

Answer 7

Chapter 23, Problem 39DSP

Interpretation Introduction

Interpretation:

The most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

Concept introduction:

Substituents attached to an aromatic ring promote metalation and control its regioselectivity.

Metalation usually takes place at the carbon atom ortho to the substituent.

Metalation can occur at C-2 of a 1, 3-disubstituted benzene as steric effects are insignificant in this case.

Directed metalation reactions are regioselective and occur at the carbon atom ortho to the acetal substituent.

Answer 8

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Answer 9

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Answer 11

Ch. 23.1 - Prob. 1P Ch. 23.3 - Problem 23.2 One of the hydroxybenzoic acids is...Ch. 23.4 - Prob. 3P Ch. 23.5 - Prob. 4P Ch. 23.6 - Problem 23.5 The compound shown was required for...Ch. 23.8 - Prob. 6P Ch. 23.8 - Prob. 7P Ch. 23.9 - Prob. 8P Ch. 23.9 - Prob. 9P Ch. 23.10 - Prob. 10P

Solution Summary: The author explains that the most reasonable structure for compound 3 in the given reaction sequence is to be chosen.

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