Organic Chemistry (Binghampton University)
16th Edition
ISBN: 9781308795010
Author: Carey
Publisher: MCG CUSTOM
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Question
Chapter 26.12, Problem 20P
Interpretation Introduction
Interpretation:
The structure of the PTH derivative isolated in the second Edman cycle of the tetrapeptide
Concept Introduction:
Edman degradation uses phenyl isothiocyanate to cleave the bond between the N-terminal amino acid and the rest of the peptide chain.
Anhydrous conditions ensure that other amide bonds are not cleaved.
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Hemoglobin A has a pI value of 5.6 whereas the variant hemoglobin M has an aspartate residue in place of the normal valine at position 85 of the alpha chain. What effect will this substitution have on the electrophoretic behavior of the protein at pH 7.0. (explain clearly the reason for your answer)
1. Taking the structure of the amino acids into account, give a comparative discussion pK values where histidine=2 and alanine=2.
Explain why the pI of lysine is the average of the pKa values of its two protonated amino groups.
Chapter 26 Solutions
Organic Chemistry (Binghampton University)
Ch. 26.1 - Prob. 1PCh. 26.2 - Prob. 2PCh. 26.2 - Prob. 3PCh. 26.3 - Prob. 4PCh. 26.3 - Prob. 5PCh. 26.4 - Prob. 6PCh. 26.4 - Prob. 7PCh. 26.4 - Prob. 8PCh. 26.5 - Prob. 9PCh. 26.6 - Prob. 10P
Ch. 26.6 - Prob. 11PCh. 26.6 - Prob. 12PCh. 26.7 - Prob. 13PCh. 26.7 - Prob. 14PCh. 26.7 - Prob. 15PCh. 26.7 - Prob. 16PCh. 26.7 - Prob. 17PCh. 26.9 - Prob. 18PCh. 26.10 - Digestion of the tetrapeptide of Problem 26.18...Ch. 26.12 - Prob. 20PCh. 26.12 - Prob. 21PCh. 26.15 - Prob. 22PCh. 26.15 - Prob. 23PCh. 26.16 - Prob. 24PCh. 26.17 - Prob. 25PCh. 26.18 - Prob. 26PCh. 26 - Prob. 27PCh. 26 - Prob. 28PCh. 26 - Prob. 29PCh. 26 - Prob. 30PCh. 26 - Prob. 31PCh. 26 - Prob. 32PCh. 26 - Prob. 33PCh. 26 - Prob. 34PCh. 26 - Prob. 35PCh. 26 - Prob. 36PCh. 26 - Prob. 37PCh. 26 - Prob. 38PCh. 26 - Prob. 39PCh. 26 - Prob. 40PCh. 26 - If you synthesized the tripeptide Leu-Phe-Ser from...Ch. 26 - Prob. 42PCh. 26 - Prob. 43PCh. 26 - Prob. 44PCh. 26 - Prob. 45DSPCh. 26 - Prob. 46DSPCh. 26 - Prob. 47DSPCh. 26 - Prob. 48DSPCh. 26 - Prob. 49DSPCh. 26 - Prob. 50DSP
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- Given: Alanine: pKa=4 Pkb=9 Histidine: pKa=2 pKb=6 and pKc=9 Taking the structure of the amino acids into account, give a comparative discussion of these pK values.arrow_forwardShow the condensation reactions that result in the formation of the tetrapeptide Asp-Gly-Ser- Gln. After you have finished the synthesis change the structure to show how it would exist in a cell at physiological pH (pH = 7).arrow_forwardHis-Met-Asp-Tyr-Phe-Ser Calculate an approximate pI (isoelectric point) for this peptide.arrow_forward
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