The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given. Concept introduction: Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid. In the first step PITC attacks the NH 2 group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH). To give: The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

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Answer 1

Question

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

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Answer 2

Question

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

Expert Solution & Answer

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See solution

Answer 3

Question

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

Expert Solution & Answer

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Answer 4

Question

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

Expert Solution & Answer

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Answer 5

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

Answer 6

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

Answer 7

Chapter 26.6, Problem 14P

Interpretation Introduction

Interpretation:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II is to be given.

Concept introduction:

Edmund degradation involves the treatment of a peptide with phenylisothiocyanate(PITC) followed by treatment with trifluoroacetic acid.

In the first step PITC attacks the NH₂ group of the N-terminal acid. In the second step the N-terminal acid residue splits from the peptide chain to yield an anilinothiazolinone(ATZ) derivative along with chain shortened peptide chain. In the third step the aqueous acid converts ATZ into a phenylthiohydantoin (PTH).

To give:

The structure of PTH derivative that will be produced in Edmund degradation of angiotension II.

Answer 8

Expert Solution & Answer

Answer 9

Expert Solution & Answer

Answer 10

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Answer 11

Ch. 26.1 - How many of the -amino acids shown in Table 26-1...Ch. 26.1 - Prob. 2P Ch. 26.1 - Prob. 3P Ch. 26.2 - Hemoglobin has pI=6.8. Does hemoglobin have a net...Ch. 26.3 - Show how you could prepare the following -amino...Ch. 26.3 - What alkyl halides would you use to prepare the...Ch. 26.3 - Prob. 7P Ch. 26.4 - There are six isomeric tripeptides that contain...Ch. 26.4 - Draw the structure of M-P-V-G, and indicate its...Ch. 26.5 - Prob. 10P

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