ORGANIC CHEMISTRY W/ALEKS
ORGANIC CHEMISTRY W/ALEKS
6th Edition
ISBN: 9781264905430
Author: SMITH
Publisher: MCG CUSTOM
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Chapter 28, Problem 58P

Researchers at Rutgers University have developed biocompatible polymers that degrade into nonsteroidal anti-inflammatory drugs. For example, the reaction of two equivalents of benzyl salicylate and one equivalent of sebacoyl chloride forms a poly (anhydride ester) called PolyAspirin, which hydrolyzes to salicylic acid (an anti-inflammatory agent) and sebacic acid, which is excreted. This technology can perhaps be used for localized drug delivery at specific sites of injury. What is the structure of PolyAspirin?

Chapter 28, Problem 58P, 30.57 Researchers at Rutgers University have developed biocompatible polymers that degrade into

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Researchers at Rutgers University have developed biocompatible polymers that degrade into nonsteroidal anti-inflammatory drugs. For example, the reaction of two equivalents of benzyl salicylate and one equivalent of sebacoyl chloride forms a poly(anhydride ester) called PolyAspirin, which hydrolyzes to salicylic acid (an anti-inflammatory agent) and sebacic acid, which is excreted. This technology can perhaps be used for localized drug delivery at specific sites of injury. What is the structure of PolyAspirin?
What is the structural difference between HDP and LDP? How does the structure account for different behaviour and nature, hence the use of a polymer?
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