Concept explainers
To discuss:
A technology that has changed the way in which scientists learn about genetics, and the way it has brought about the change.
Introduction:
Due to increasing developments in genomic technology, the study of genetics has become important in clinical practice and science. Over the last decade, substantial steps have been taken to discover the underlying causes of genetic disorders.In addition, genetic testing methods have become widely available and feasible even for small-scale laboratories, especially after the completion of the Human Genome Project, which coincided with advances in computer technology. Through the introduction of genetic testing for personalized medicine, we are at the beginning of an age that will offer new horizons for human health.
Explanation of Solution
Despite the creation of high resolution techniques that identified several documented or unknown genetic syndromes, many cases of submicroscopic aberrations that were not evident at resolution between 500 and 1000 bands remained undiagnosed. A new technique named fluorescence in situ hybridization (FISH) was developed in the field of molecular cytogenetics. Molecular genetics and cytogenetics have been bridged by this approach. FISH detects unique
Chromosome rearrangements could be identified more effectively with improved resolution of the FISH in both interphase and metaphase nucleus that might be used for study and clinical diagnosis. FISH also supported the possibility for the simultaneous use of one or more DNA probes by marking various colors or colour combinations. For FISH, many types of probes can be used.Whole-chromosomal painting probes, chromosomal-arm painting probes, and centromeric, subtelomeric, and locus-specific probes are some of the examples available for the identification of particular constitutional and acquired chromosomal defects.
Thus, the fluorescence in situ hybridization can changed the way in which scientists learn about genetics.
Chapter 29 Solutions
Biology Illinois Edition (Glencoe Science)
Additional Science Textbook Solutions
Campbell Essential Biology (7th Edition)
Microbiology: An Introduction
Human Anatomy & Physiology (2nd Edition)
Campbell Biology (11th Edition)
Campbell Biology: Concepts & Connections (9th Edition)
Microbiology: An Introduction
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education