Introduction:
The innate immune responses are those immune responses, which are nonspecific and can act against both non-self and self-antigen. The innate immune response can be either immediate or induced.
Answer to Problem 1Q
Correct answer:
The correct answer is option (b), (d) and (g).
Explanation of Solution
Explanation/justification for the correct answer:
Option (b) Commensal organism. The commensal organism play a vital role in immediate immune response.
Option (d) alternative pathway of complement system. The alternate pathway is triggered by the binding of the C3b directly to the immune system when C3b directly binds to microbe. It is a type of immediate response.
Option (g) Defensins. The defensins are the peptides present in the plasma, which act immediate against the pathogens as well as non-enveloped viruses.
Explanation for the incorrect answer:
Option (a) Scavenger receptors. The scavenger receptors are present in the macrophages, which bind to the bacteria or other pathogen for the phagocytosis. It is an induced response. Hence, it is an incorrect answer.
Option (c) dectin 1. The dectin is also a membrane recognition protein, which has an important role in antifugal innate immunity. It is also a part of induced innate immunity. Hence, it is an incorrect answer.
Option (e) MyD88. The MyD88 related pathways activate TLR4 signaling and helps in getting rid of the bacteria. It is also associated with late induced innate immunity response. Hence, it is an incorrect option.
Option (f) CXCL8. It is also known as interleukin 8, produced by macrophages. It is also a induced response. Hence, it is an incorrect answer.
Option (h) NOD1 and NOD2. It is an intracellular receptor for bacterial peptidoglycan fragmentation. It is also caused by induction of the complement system. Hence, it is an incorrect answer.
Option (i) lectin pathway of the complement system. It is a type of cascade response of the activation of the complement system. It proceeds by the action of C4 and C2. Hence, it is an incorrect answer.
The correct answer is option (b), (d) and (g).
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