GENETIC ANALYSIS: AN INTEG. APP. W/MAS
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
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Chapter 3, Problem 31P

While examining a young tortoiseshell cat, you and the veterinarian you are interning with get a surprise - the cat is male, not female ! from your undergraduate genetics course, you recall that tortoiseshell coats are produced by the random X - inactivation that takes place in mammalian females. The veterinarian orders a chromosome analysis of the cat and finds that he is XXX : He has two X chromosomes and one Y chromosome. Help the veterinarian figure out how a tortoiseshell cat could be male. (Hint : Think about X - inactivation in mammals with two X chromosomes.)

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XX individuals can be sex-reversed males if one of their X chromosomes contains a translocated portion of the Y chromosome that includes the SRY gene. In light of what you now know about X-chromosome inactivation, it seems that this karyotype might have more complex consequences. In fact, although most such males are completely sex-reversed, X-chromosome inactivation can cause some of these XX males to have varying degrees of residual female characteristics. a. X-chromosome inactivation in normal XX embryos occurs earlier in development than SRY production in normal XY embryos. When present on a translocation X chromosome, SRY is subject to inactivation. Formulate a hypothesis to explain why many XX individuals with a translocation X chromosome that includes the SRY gene are not completely sex-reversed (male). b. Based on your answer to part (a), why do you think some individuals with this karyotype are completely sex-reversed?
Cat fur coat color genetics is interesting. Orange fur is dominant (''B'') to black fur (''b'') and piebald, which is white spotting, is dominant (''S'') to non-white-spotted (''s''). Both of those genes are located on the X chromosome. In addition, in cats, somatic cells exhibit X-inactivation randomly, which explains why there are tortoiseshell cats (when heterozygous, have orange and black spots) as well as calico cats (orange and black but also with white spots). An orange and white spotted male is mated with a tortoiseshell female. State the genotype of the male and the female.
Although most tortoiseshell cats are female, a litter of kittens will occasionally contain a male tortoiseshell. Which of the following can explain tortoiseshell coat color in a male kitten? Please explain in detail. The male kitten has an extra Y chromosome The male kitten has an extra X chromosome The male kitten has no X chromosome The male kitten cannot carry out X-inactivation

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GENETIC ANALYSIS: AN INTEG. APP. W/MAS

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