CAMPBELL BIOLOGY IN FOCUS-TEXT,AP ED.
CAMPBELL BIOLOGY IN FOCUS-TEXT,AP ED.
3rd Edition
ISBN: 9780136811206
Author: Urry
Publisher: SAVVAS L
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Chapter 32.3, Problem 2CC
Summary Introduction

To explain:

The negative feedback in thermoregulation differs from feedback inhibition in an enzyme catalyzed biosynthetic process.

Introduction:

Negative feedback occurs when the end product of an enzyme interferes or decreases the effect of the same enzyme that produced it. The feedback inhibition mechanism is the cellular process in which the end product of an enzyme inhibits the production of the same enzyme that produced it. By this process there is the maintenance of the amount of enzyme required. Both processes help in the regulation of the metabolic processes.

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MAKE CONNECTIONS Step 3 in Figure 9.9 is a major pointof regulation of glycolysis. The enzyme phosphofructokinaseis allosterically regulated by ATP and related molecules (seeConcept 8.5). Considering the overall result of glycolysis,would you expect ATP to inhibit or stimulate activity of thisenzyme? Explain. (Hint: Make sure you consider the role of ATPas an allosteric regulator, not as a substrate of the enzyme.)
Q1: Why is it important that enzymes are not permanently altered when they bind with substrate molecules? Q2: How would a higher temperature or higher salt concentration make it more difficult for an enzyme to function effectively? Q3: If a cell was unable to produce a particular enzyme necessary for a metabolic pathway, describe how the absence of that enzyme would affect the cell.
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