BIOLOGY:CONCEPTS+INV>CUSTOM<
BIOLOGY:CONCEPTS+INV>CUSTOM<
18th Edition
ISBN: 9781307311655
Author: Hoefnagels
Publisher: MCG/CREATE
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Chapter 33, Problem 9WIO
Summary Introduction

To determine:

The reason, why the fluids deep in medulla of the kidney have a much higher solute concentration than those in the cortex and from where do the solutes in the medulla come. Also, determine the role of high solute concentration, in the functioning of the nephron loop.

Concept introduction:

The processes of urine formation, take place in the nephrons of kidneys, and involve the filtration, reabsorption, and secretion. The process of filtration begins at the glomerulus, which contains the initial filtrate. The concentration of this filtrate changes throughout the processes of filtration, reabsorption, and secretion, and finally results in the formation of urine.

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The fluids deep in the medulla of the kidney have a much highersolute concentration than those in the cortex. Where do the solutes inthe medulla come from? What is the role of that high soluteconcentration in the functioning of the nephron loop?
Which of the following statements concerning the medullary verticle osmotic gradient is TRUE:  W. The loops of Henle of juxtamedullary nephrons establish a medullary osmotic gradient by means of countercurrent multiplicationX. The vasa recta enable the medulla to be supplied with blood while conserving the medullary osmotic gradient Y. The medullary osmotic gradient permits excretion of urine of differing concentrationsZ. The collecting tubules of all nephrons descend through the medullary osmotic gradient before emptying into the renal pelvis Select one: a. if only W, X and Y are correct b. if only W and Y are correct c. if only X and Z are correct d. if only Z is correct e. if all are correct
Match correct function with regions of the nephron. Region of Nephron Function V Filtration of blood to make filtrate. Mainly selective tubular reabsorption of glucose, amino acids, Na then CI, H,0 follows by v osmosis. Reabsorption of bicarbonate. Also tubular secretion of NH, and H; tubular secretion of drugs (e.g. penicillin). v To create and maintain the concentration gradient across the medulla. v Impermeable to NaCl, permeable to H,0. Water leaves filtrate (in response to concentration of surrounding interstitial fluid) as it descends making the filtrate more concentrated. v Impermeable to H,0, Na is pumped out of the tubule, (CI follows) so filtrate becomes less concentrated as it ascends. H2O reabsorption depending on ADH. Tubular secretion of NH", K and H depending on need. Reabsorption or secretion of bicarbonate depending on need. Loop of Henle (descending limb) V Reabsorption of H2O depending on levels of ADH. Loop of Henle (descending limb) Loop of Henle (as a unit) Loop…
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