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MindTap Biology, 1 term (6 months)...

14th Edition
Cecie Starr + 3 others
ISBN: 9781305269842

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BuyFindarrow_forward

MindTap Biology, 1 term (6 months)...

14th Edition
Cecie Starr + 3 others
ISBN: 9781305269842

Textbook Problem

Building Better Bones Tiffany, shown in FIGURE 35.22, was born with multiple fractures in her arms and legs. By age six, she had undergone surgery to correct more than 200 bone fractures. Her fragile, easily broken bones are symptoms of osteogenesis imperfecta (OI), a genetic disorder caused by a mutation in a gene for collagen. As bones develop, collagen forms a scaffold for deposition of mineralized bone tissue. The scaffold forms improperly in children with OI. FIGURE 35.22 also shows the results of a test of a new drug. Treated children, all less than two years old, were compared to similarly affected children of the same age who were not treated with the drug.

  Vertebral  
Treated area in cm2 Fractures
child (Initial) (Final) per year
1 14.7 16.7 1
2 15.5 16.9 1
3 6.7 16.5 6
4 7.3 11.8 0
5 13.6 14.6 6
6 9.3 15.6 1
7 15.3 15.9 0
8 9.9 13.0 4
9 10.5 13.4 4
Mean 11.4 14.9 2.6
  Vertebral  
Treated area in cm2 Fractures
child (Initial) (Final) per year
1 18.2 13.7 4
2 16.5 12.9 7
3 16.4 11.3 8
4 13.5 7.7 5
5 16.2 16.1 8
6 18.9 17.0 6
Mean 16.6 13.1 6.3

images

FIGURE 35.22 Results of a clinical trial of a drug treatment for osteogenesis imperfecta (OI), which affects the child shown at right. Nine children with OI received the drug. Six others were untreated controls. Surface area of certain vertebrae was measured before and after treatment. Fractures occurring during the 12 months of the trial were also recorded.

3. How did the rate of fractures in the two groups compare?

Summary Introduction

To compare: The rate of fractures in the treated and untreated groups.

Concept Introduction: Bones are the specialized connective tissue that surround the living cells.  The human skeleton of an adult consists of 206 bones. The main functions of bone are as follows: for the movement, to store minerals, to protect the organs and to produce the blood cells through red marrow. Osteogenesis imperfecta is also known as brittle bone disease. It is a group of genetic disorder that can adversely affects the bones of our body. The main symptom of this disorder is the easy breakage of bones. It is mainly caused due to the mutation in the collagen genes.

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