Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 38, Problem 24RQ
Botulinum toxin causes flaccid paralysis of the muscles, and is used for cosmetic purposes under the name Botox. Which of the following iis the most likely mechanism of action of Botox?
- Botox decreases the production of acetylcholinesterase
- Botox increases calcium release from the sarcoplasmic reticulum
- Botox blocks the ATP binding site in actin
- Botox decreases the release of acetylcholine from motor neurons.
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Tetanus is a disease caused by Clostridium tetani characterized by muscle spasms. Just like the toxin produced by Clostridium botulinum, this toxin produced by C. tetani interferes with muscle contractions. Where botulina toxin causes paralysis, C. tetani toxin causes muscle spasms and painful contractions lasting minutes at a time. Additional symptoms include stiffness and rigidity of muscles. Using your knowledge of how muscles contract explain what steps within a muscle contraction are being interfered with to cause these symptoms?
Which statement or statements describe why depletion of ATP after death leads to rigor mortis?
Select all that apply.
ATP is required to move tropomyosin back over the active sites of thin filaments.
ATP is required for myosin thick filaments to detach from actin thin filaments.
ATP is required to pump calcium back into the sarcoplasmic reticulum.
ATP is required for the action potential to spread across the sarcolemma.
Which of the following step(s) about the excitation of skeletal muscle is/are incorrect?
1. Acetylcholine is released and binds to motor end plate receptors
2. An action potential is created and moves down T-tubules
3. Calcium is released from the sarcoplasmic reticulum
4. Calcium ions bind to tropomyosin to shift troponin off the binding sites for cross-bridging
5. Myosin forms cross-bridges and binds with actin to pull it towards middle of sarcomere
Chapter 38 Solutions
Biology 2e
Ch. 38 - Figure 38.19 Which of the following statements...Ch. 38 - Figure 38.37 Which of the following statements...Ch. 38 - Figure 38.38 The deadly nerve gas Sarin...Ch. 38 - The forearm consists of the radius and ulna radius...Ch. 38 - The pectoral girdle consists of the: clavicle and...Ch. 38 - All of the following are groups of vertebrae...Ch. 38 - Which of these is a facial bone? frontal occipital...Ch. 38 - Which of the following is not a true statement...Ch. 38 - The Haversian canal: is arranged as rods or plates...Ch. 38 - The epiphyseal plate: is arranged as rods or...
Ch. 38 - The cells responsible for bone resorption are...Ch. 38 - Compact bone is composed of trabeculae compacted...Ch. 38 - Osteoporosis is a condition where bones become...Ch. 38 - While assembling a skeleton of a new species, a...Ch. 38 - Synchondroses and symphyses are synovial joints...Ch. 38 - The movement of bone away from the midline of the...Ch. 38 - Which of the following is not a characteristic of...Ch. 38 - The elbow is an example of which type of joint?...Ch. 38 - A high ankle sprain iis an injury caused by over...Ch. 38 - In relaxed muscle, the myosin-binding site on...Ch. 38 - The cell membrane of a muscle fiber is called a...Ch. 38 - The muscle relaxes if no new nerve signal arrives....Ch. 38 - The ability of a muscle to generate tension...Ch. 38 - Botulinum toxin causes flaccid paralysis of the...Ch. 38 - What are the major differences between the male...Ch. 38 - What are the major differences between the pelvic...Ch. 38 - Both hydrostatic and exoskeletons can protect...Ch. 38 - Scoliosis is a medical condition where the spine...Ch. 38 - What are the major differences between spongy bone...Ch. 38 - What are the roles of osteoblasts, osteocytes, and...Ch. 38 - Thalidomide was a morning sickness drug given to...Ch. 38 - What movements occur at the hip joint and knees as...Ch. 38 - What movements) occur(s) at the scapulae when you...Ch. 38 - Describe the joints and motions involved in taking...Ch. 38 - How would muscle contractions be affected if ATP...Ch. 38 - What factors contribute to the amount of tension...Ch. 38 - What effect will low blood calcium have on...Ch. 38 - Skeletal muscles can only produce a mechanical...
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- Figure 38.37 Which of the following statements about muscle contraction is true? The power stroke occurs when ATP is hydrolyzed to ADP and phosphate. The power stroke occurs when ADP and phosphate dissociate from the myosin head. The power stroke occurs when ADP and phosphate dissociate from the actin active site. The power stroke occurs when Ca2+ binds the calcium head.arrow_forwardSkeletal muscle contraction requires _________. a. calcium ions b. ATP c. arrival of a nerve impulse d. all of the abovearrow_forwardDepolarization of the sarcolemma means ________. the inside of the membrane has become Less negative as sodium ions accumulate the outside of the membrane has become less negative as sodium ions accumulate the inside of the membrane has become more negative as sodium ions accumulate the sarcolemma has completely lost any electrical chargearrow_forward
- Motor neurons innervate muscle fibers at specialized synapses called_______ . The release of acetylcholine at these synapses ultimately triggers an action potential in the muscle fiber, which invades the interior of the fiber through_____ and stimulates the release of calcium ions from the_______ .arrow_forwardA motor unit associated with the stimulation of skeletal muscle is designated as a 1:8 motor unit. Which of the following statements is correct? The motor unit consists of one somatic neuron and 8 myofibers (muscle fibers) Each of the myofibers in the motor unit is innervated by more than one neuron It is part of the autonomic nervous system The neuron in the motor unit is an afferent neuronarrow_forwardAn ion that is essential for muscle contraction is Ca2+. Which of the following statements about the calcium ion and muscle contractions is TRUE? Select one: a. Muscle contractions can occur whether Ca2+ concentrations are high or low. b. Ca2+ binds to the tropin-tropomyosin protein complex shifting it out of the way and allows the myosin to bind to the actin so contraction can occur. c. When Ca2+ concentrations are high, tropomyosin inhibits myosin binding and the muscle is relaxed. d. Ca2+ ions are stored in the sacroplasmic reticulum during the muscle contractions. I do not know which one isarrow_forward
- An ion that is essential for muscle contraction is Ca2+. Which of the following statements about the calcium ion and muscle contractions is TRUE? Select one: a. Muscle contractions can occur whether Ca2+ concentrations are high or low. b. Ca2+ binds to the tropin-tropomyosin protein complex shifting it out of the way and allows the myosin to bind to the actin so contraction can occur. c. When Ca2+ concentrations are high, tropomyosin inhibits myosin binding and the muscle is relaxed. d. Ca2+ ions are stored in the sacroplasmic reticulum during the muscle contractions. i do not knwo which one is the answerarrow_forwardFrom the following choices, choose the THREE, that would result in prevention of muscle contraction (in other words, which three descriptive changes below would result in flaccid paralysis of a muscle). exocytosis of acetylcholine is constant, even without action potential injection of botulinum toxin calcium cannot be pumped back into the terminal cisternae acetylcholine receptor remains open to sodium active sites on actin a permanently exposed dramatically increase the activity of acetylcholinesterase calcium cannot bind troponinarrow_forwardWhich of the following is associated with smooth muscle contraction? Troponin as calcium-sensing protein. Contraction based on the sliding filaments theory. Calcium-induced calcium release mechanism. Electromechanical calcium release mechanism. Contraction requires myosin light-chain kinase activityarrow_forward
- The depletion of ATP in muscle cells causes ____. myosin heads to remain bound to actin calcium ions to be released from the sarcoplasmic reticulum myosin-binding sites on actin to be blocked again by tropomyosin. ligand-gated sodium channels to close againarrow_forwardCalcium ions are responsible for unmasking of active site on which protein for cross bridge activity during muscle contraction? 1.Troponin 2.Tropomyosin 3.Myosin 4.Actinarrow_forwardRecently, it has been observed that several muscle diseases and disorders are linked to problems with triad structure and function.One such disorder is called malignant hyperthermia, a dire hypermetabolic response to certain inhaled anesthetics such as halothane. Muscles become very rigid due to excessive contraction (especially the masseter muscle), the body temperature spikes, andmuscles break down. Death is certain if not treated. Given the principal symptoms of malignant hyperthermia, what is its likely cause?Propose a theoretical mechanism for a treatment that would dampen the deleterious effects of this disorder.arrow_forward
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