Concept explainers
Spinal fluid proteins and Alzheimer’s A research study published in 2010 in the Archives of Neurology investigated the relationship between the results of a spinal fluid test and the presence of Alzheimer’s disease. The study included 114 patients with normal memories, 200 with memory problems, and 102 with Alzheimer’s disease. Each individual’s spinal fluid was analyzed to detect the presence of two types of proteins. Almost everyone with Alzheimer’s had the proteins in their spinal fluid. Nearly three quarters of the group with memory problems had the proteins, and each such member developed Alzheimer’s within five years. About one third of those with normal memories had the proteins, and the researchers suspect that those individuals will develop memory problems and eventually Alzheimer’s.
- a. Identify the explanatory and response variable(s).
- b. Was this an experimental or nonexperimental study? Why?
- c. Would it be possible to design this study as an experiment? Explain why or why not.
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Statistics: The Art and Science of Learning from Data (4th Edition)
- Population Genetics In the study of population genetics, an important measure of inbreeding is the proportion of homozygous genotypesthat is, instances in which the two alleles carried at a particular site on an individuals chromosomes are both the same. For population in which blood-related individual mate, them is a higher than expected frequency of homozygous individuals. Examples of such populations include endangered or rare species, selectively bred breeds, and isolated populations. in general. the frequency of homozygous children from mating of blood-related parents is greater than that for children from unrelated parents Measured over a large number of generations, the proportion of heterozygous genotypesthat is, nonhomozygous genotypeschanges by a constant factor 1 from generation to generation. The factor 1 is a number between 0 and 1. If 1=0.75, for example then the proportion of heterozygous individuals in the population decreases by 25 in each generation In this case, after 10 generations, the proportion of heterozygous individuals in the population decreases by 94.37, since 0.7510=0.0563, or 5.63. In other words, 94.37 of the population is homozygous. For specific types of matings, the proportion of heterozygous genotypes can be related to that of previous generations and is found from an equation. For mating between siblings 1 can be determined as the largest value of for which 2=12+14. This equation comes from carefully accounting for the genotypes for the present generation the 2 term in terms of those previous two generations represented by for the parents generation and by the constant term of the grandparents generation. a Find both solutions to the quadratic equation above and identify which is 1 use a horizontal span of 1 to 1 in this exercise and the following exercise. b After 5 generations, what proportion of the population will be homozygous? c After 20 generations, what proportion of the population will be homozygous?arrow_forwardQuestion Red Wine and Weight LossResveratrol, a compound in grapes and red wine, has been shown to promote weight loss in rodents and now in a primate.1 Lemurs fed a resveratrol supplement for four weeks had decreased food intake, increased metabolic rate, and a reduction in seasonal body-mass gain compared to a control group. Suppose a hypothetical study is done for a different primate species, with one group given a resveratrol supplement and the other group given a placebo. We wish to see if there is evidence that resveratrol increases the mean metabolism rate for this species. (This exercise presents hypothetical data. We will see the results from the actual study later in this chapter.) (a) State the null and alternative hypotheses.Let group 1 be the species taking a resveratrol supplement and let group 2 be the species taking a placebo.arrow_forwardIn a study conducted in the Science Department of Faculty of Science, Technology and Human Development in a University; the researcher examined the influence of the drug succinylcholine on the circulation levels of androgens in the blood. Blood samples from wild, free-ranging deer were obtained via the jugular vein immediately after an intramuscular injection of succinylcholine using darts and a capture gun. Deer were bled again approximately 30 minutes after the injection and then released. The level of androgens at time of capture and 30 minutes later, measured in nanograms per milliliter (ng/ml), for 15 deers as in Table Q1. Assuming that the populations of androgen at time of injection and 30 minutes later are normally distributed:i) Find the average and standard deviation of this studyii)Determine the critical region of this problem.iii) Test at the 0.05 level of significance whether the androgen concentrations are altered after 30 minutes of restraint.arrow_forward
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- Functions and Change: A Modeling Approach to Coll...AlgebraISBN:9781337111348Author:Bruce Crauder, Benny Evans, Alan NoellPublisher:Cengage Learning