From the given information, the configuration of naproxen should be determined. Concept Introduction: Enantiomeric excess: The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value. If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer. The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by ee % = observed specific rotation specific rotation of the pure enantiomer ×100

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Answer 1

Question

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

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Students have asked these similar questions

Naproxen, a nonsteroidal anti-inflammatory drug that is the active ingredient in Aleve, has a specific rotation of +66. One commercial preparation results in a mixture with a 97% enantiomeric excess. a. Does naproxen have the R or the S configuration? b. What percent of each enantiomer is obtained from the commercial preparation?

Citalopram is an antidepressant pharmaceutical that is sold as a racemic mixture. However, it is known that the (S) enantiomer is 30x more biologically active than the (R) enantiomer. Draw the (S) configuration.

Trabectedin, shown in a ball-and-stick model on the cover of this text, is an anticancer drug sold under the trade name Yondelis. a. Locate the stereogenic centers in trabectedin. b.What is the maximum number of stereoisomers possible for trabectedin? c.Draw the enantiomer. d.Draw a diastereomer. e.If the specific rotation of trabectedin is +41.5, what is the [α] of a solution that contains 75% trabectedin and 25% of its enantiomer?f . What is the ee of a solution with [α] = +10.5?

Answer 2

Question

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Expert Solution & Answer

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Answer 3

Question

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Expert Solution & Answer

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Answer 4

Question

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Expert Solution & Answer

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Answer 5

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Answer 6

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Answer 7

Chapter 4.10, Problem 24P

(a)

Interpretation Introduction

Interpretation:

From the given information, the configuration of naproxen should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Answer 8

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Answer 9

(b)

Interpretation Introduction

Interpretation:

From the given information, the percentage of each isomer of Naproxen obtained from the commercial preparation should be determined.

Concept Introduction:

Enantiomeric excess:

The equal amount of isomers in the mixture is called racemic mixture and it have a 0 specific rotation so it is optically inactive value.

If a mixture contains unequal mixture of isomers means it can be optically active but the specific rotation value can varied by which enantiomer is present more than other isomer.

The excess of one isomer than other isomer in the mixture is known as enantiomeric excess (ee %), it is given by

ee % = observed specific rotationspecific rotation of the pure enantiomer×100

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 4.1 - Prob. 2P Ch. 4.1 - Prob. 3P Ch. 4.1 - Prob. 4P Ch. 4.1 - Prob. 5P Ch. 4.1 - Which of the roll owing compounds have a dipole...Ch. 4.2 - Prob. 7P Ch. 4.3 - Prob. 8P Ch. 4.4 - Prob. 10P Ch. 4.4 - Prob. 11P Ch. 4.6 - Prob. 12P

Solution Summary: The author explains that the configuration of Naproxen should be determined from the given information. Enantiomeric excess is the equal amount of isomers in the mixture called racemic mixture.

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