In a January 15, 1998, article, the New England Journal of Medicine (338:141–146) reported on the utility of using computerized tomography (CT) as a diagnostic test for patients with clinically suspected appendicitis. In at least 20% of patients with appendicitis, the correct diagnosis was not made. On the other hand, the appendix was normal in 15% to 40% of patients who under- went emergency appendectomy. A study was designed to determine the prospective effectiveness of using CT as a diagnostic test to improve the treatment of these patients. The study examined 100 consecutive patients suspected of having acute appendicitis who presented to the emergency department or were referred there from a physician’s office. The 100 patients underwent a CT scan, and the surgeon made an assessment of the presence of appendicitis for each of the patients. The final clinical outcomes were determined at surgery and by pathological examination of the appendix after appendectomy or by clinical follow-up at least 2 months after CT scanning.
The 1996 rate of occurrence of appendicitis was approximately P(C) − .00108.
- a. Find the sensitivity and specificity of the radiological determination of appendicitis.
- b. Find the probability that a patient truly had appendicitis given that the radiological determination was definitely appendicitis (DA).
- c. Find the probability that a patient truly did not have appendicitis given that the radiological determination was definitely appendicitis (DA).
- d. Find the probability that a patient truly did not have appendicitis given that the radiological determination was definitely not appendicitis (DNA).
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An Introduction to Statistical Methods and Data Analysis
- The National Institute of Mental Health published an article stating that in any two-year period, approximately 10.5percent of American adults suffer from depression or a depressive illness. Suppose that in a survey of 150 people in a certain town, eight of them suffered from depression or a depressive illness. If you were conducting a hypothesis test to determine if the true proportion of people in that town suffering from depression or a depressive illness is lower than the percent in the general adult American population, what would the null and alternative hypotheses be?arrow_forwardThe article “The Effects of a Low-Fat, Plant-Based DietaryIntervention on Body Weight, Metabolism, and InsulinSensitivity in Postmenopausal Women” (Amer. J. of Med.,2005: 991–997) reported on the results of an experiment inwhich half of the individuals in a group of 64 postmenopausaloverweight women were randomly assigned to a particularvegan diet, and the other half received a diet based on NationalCholesterol Education Program guidelines. The sample meandecrease in body weight for those on the vegan diet was 5.8kg, and the sample SD was 3.2, whereas for those on the control diet, the sample mean weight loss and standard deviationwere 3.8 and 2.8, respectively. Does it appear the true averageweight loss for the vegan diet exceeds that for the control dietby more than 1 kg? Carry out an appropriate test of hypotheses at significance level .05 based on calculating a P-valuearrow_forwardThe article “Effects of Diets with Whole Plant-Origin Proteins Added with Different Ratiosof Taurine:Methionine on the Growth, Macrophage Activity and Antioxidant Capacity ofRainbow Trout (Oncorhynchus mykiss) Fingerlings” (O. Hernandez, L. Hernandez, et al.,Veterinary and Animal Science, 2017:4-9) reports that a sample of 210 juvenile rainbowtrout fed a diet fortified with equal amounts of the amino acids taurine and methionine for aperiod of 70 days had a mean weight gain of 313 percent with a standard deviation of 25, while 210 fish fed with a control diet had a mean weight gain of 233 percent with a standard deviation of 19. Units are percent. Find a 99% confidence interval for the difference in weight gain on the two diets.arrow_forward
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