PRESCOTT'S MICROBILOGY
PRESCOTT'S MICROBILOGY
11th Edition
ISBN: 9781264075515
Author: WILLEY
Publisher: MCG
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Chapter 42, Problem 1RC
Summary Introduction

To determine: The differences and similarities between at least five different classes of antibiotics.

Introduction: The antibiotic is a microbial product and their molecular derivatives that kills or inhibits the growth of micro-organisms. The antibiotics are used to treat various types of diseases caused by bacteria and other microbes. The penicillin was the very first antibiotic discovered naturally from a fungus known as penicillium.

Expert Solution & Answer
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Explanation of Solution

There are various types of microbes, such as bacteria and fungi, that produces many employed antibiotics. The synthetic antibiotics and chemotherapeutic drugs are ciprofloxacin, ionized, dapsone, and many more, whereas some are also semisynthetic, which have been genetically modified by adding chemical groups (ampicillin). The similarity between penicillin, cephalosporins, vancomycin, aminoglycosides, and fluoroquinolones is that they have a cidal effect, which is that they kill bacteria without the help of the patient’s immune system.

The differences between the antibiotics are as follows.

S. NoCharacteristicsPenicillinCephalosporinsVancomycinAminoglycosidesFluoroquinolones
1.Mechanism of actionThey usually inhibit the enzymes involving in the cross-linking chains of peptidoglycan.They usually inhibit the enzymes involving in the PBP cross-linking the chains of peptidoglycan.It also prevents the transpeptidation by binding to amino acids at the end of the peptide chains.It binds to the ribosomal subunit and interferes with protein synthesis.They inhibit the DNA replication
2.examplespenicillin, penicillin VCephalothin, cefoxitinVancomycinNeomycin, gentamicinLevofloxacin, ciprofloxacin
3.Side effectsDiarrhea, anemiaAllergic reactionsOtotoxic and nephrotoxicRenal damage, nauseaHeadaches, allergic reactions.
4.Derived fromPenicillium notatumAcremoniumAmycolatopisStreptomyces griseus4-quinolone molecule

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