EBK HUMAN PHYSIOLOGY
8th Edition
ISBN: 9780134704227
Author: Silverthorn
Publisher: YUZU
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Chapter 4.4, Problem 18CC
Summary Introduction
Introduction: Lactate dehydrogenase is an enzyme which catalyzes the reaction where lactate is converted to pyruvate. This reaction is important for the production of energy in the body, therefore lactate dehydrogenase is an important enzyme.
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A sample of glycogen from a patient with liver disease is incubated with orthophosphate, phosphorylase, the transferase, and the debranching enzyme ( α -1,6- glucosidase). The ratio of glucose 1- phosphate to glucose formed in this mixture is 100. What is the most likely enzymatic deficiency in this patient?
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Chapter 4 Solutions
EBK HUMAN PHYSIOLOGY
Ch. 4.1 - Which biomolecules always include nitrogen in...Ch. 4.1 - Prob. 2CCCh. 4.1 - What is the difference between potential energy...Ch. 4.1 - Prob. 4CCCh. 4.2 - Prob. 5CCCh. 4.2 - Prob. 6CCCh. 4.2 - Prob. 7CCCh. 4.3 - Prob. 8CCCh. 4.3 - Prob. 9CCCh. 4.3 - Prob. 10CC
Ch. 4.3 - Prob. 11CCCh. 4.4 - Name five ways in which cells regulate the...Ch. 4.4 - Prob. 13CCCh. 4.4 - Prob. 14CCCh. 4.4 - Match each component on the left to the...Ch. 4.4 - Prob. 16CCCh. 4.4 - How is the separation of mitochondria into two...Ch. 4.4 - Prob. 18CCCh. 4.4 - Prob. 19CCCh. 4.4 - Prob. 20CCCh. 4.4 - What does the name RNA polymerase tell you about...Ch. 4.4 - Explain in one or two sentences the relationship...Ch. 4.4 - Prob. 23CCCh. 4.4 - List three general types of posttranslational...Ch. 4.4 - Prob. 25CCCh. 4 - List the three basic forms of work and give a...Ch. 4 - Prob. 2RQCh. 4 - Prob. 3RQCh. 4 - Prob. 4RQCh. 4 - Prob. 5RQCh. 4 - Prob. 6RQCh. 4 - Match each definition in the left column with the...Ch. 4 - Prob. 8RQCh. 4 - Organic molecules that must be present in order...Ch. 4 - In an oxidation-reduction reaction, in which...Ch. 4 - Prob. 11RQCh. 4 - Prob. 12RQCh. 4 - Prob. 13RQCh. 4 - Metabolic regulation in which the last product of...Ch. 4 - Prob. 15RQCh. 4 - Prob. 16RQCh. 4 - Create maps using the following terms.Ch. 4 - Prob. 18RQCh. 4 - Prob. 19RQCh. 4 - Prob. 20RQCh. 4 - Prob. 21RQCh. 4 - Briefly describe the processes of transcription...Ch. 4 - On what molecule does the anticodon appear?...Ch. 4 - Is the energy of ATPs phosphate bond an example of...Ch. 4 - Prob. 25RQCh. 4 - Prob. 26RQCh. 4 - Prob. 27RQCh. 4 - Prob. 28RQ
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- Why Alpha-Ketoglutarate dehydrogenase (a-KGDH) called deficiency? What are the probable causes? Explain.arrow_forwardAre any of the intermediates in the β-oxidation pathway chiral? Explain.arrow_forwardFatty acid beta-oxidation consists of 4 steps that are repeated multiple times. Explain the purpose of step 2 and step 3 respectively. (You don’t need to provide names of enzymes or intermediates!).arrow_forward
- The “bridge reaction”, using pyruvate dehydrogenase, is highly exergonic and is essentially irreversible. Name the 3 outcomes (name any activated carriers produced, name the molecule that is produced from losing one carbon atom from pyruvate, and name any modification to the remaining two carbon compound of interest ) of the separate enzyme activities found within the large dehydrogenase complex.arrow_forwardA sample of glycogen from a patient with liver disease is incubated with Pi, normal glycogen phosphorylase, and normal debranching enzyme. The ratio of G1P to glucose formed in the reaction mixture is 100. What is the patient’s most probable enzymatic defi ciency?arrow_forwardThe complete oxidation of glucose 6-phosphate derived from free glucose yields 30 molecules ATP, whereas the complete oxidation of glucose 6- phosphate derived from glycogen yields 31 molecules of ATP. Account for this difference.arrow_forward
- In the B-oxidation of a saturated, even chain fatty acid, four basic steps are involved. Describe these reactions using the degradation of palmitic acid as an example.arrow_forwardTo what class of enzymes does hexokinase belong? Describe in general the reaction it catalyzes.arrow_forwardLactate dehydrogenase isoforms contain "H" and "M" subunits. In total, how many subunits are found in the isoforms? C 2 3 4 6 8arrow_forward
- The same reactions that were seen in the process of converting pyruvate to acetyl-S-CoA, occur in step ____ of the citric acid cycle as ____________ is converted to _________________.arrow_forwardDescribe the reaction catalyzed by each enzyme: (a) aspartate transaminase; (b) glyceraldehyde 3-phosphate dehydrogenase.arrow_forwardVon Gierke’s disease is also known as glycogen storage disease type I. Patients with von Gierke’s disease lackglucose 6-phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis (elevated lactate levels in the blood), especially during strenuous exercise. Explain why these symptoms occur. What chemical reaction does this enzyme catalyze? Which pathways involve this enzyme? Lacking thisthe enzyme will cause impairment of which pathways?• Pls consider what pathways are affected by Von Gierke’s disease. Include in your explanation involving Cori’s cycle. can you please do not write by your hand? I mean computer if you can. thank youarrow_forward
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