Campbell Biology: Australian And New Zealand Edition + Mastering Biology With Etext
11th Edition
ISBN: 9781488687075
Author: Lisa, A. Urry
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 48.4, Problem 2CC
Some pesticides inhibit acetylcholinesterase, the enzyme that breaks down acetylcholine. Explain how these toxins would affect EPSPs produced by acetylcholine.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The graph shows a tracing of membrane potential change during the course of an action potential in a typical neuron. Predict the effect of exposure to the following neurotoxins. Briefly explain how you would expect the action potential to change in the presence of each toxin and why.
A toxin produced by puffer fish which specifically binds to voltage-gated sodium channels and blocks the flow of sodium ions through the channel.
A toxin found in scoprion venom which slows the closure of voltage-gated sodium channel inactivation gates.
Assume that the cell is normally brought to threshold by an electrical stimulus applied to it, so that any change is due only to the presence of the toxin
Precise values for voltage and duration are not important, just a general trend in how the action potential may differ from the typical trace shown is expected.
Acetylcholine is an excitatory neurotransmitter that is responsible for initiating muscle movement. Consider the
scenario where a mouse was bitten by a snake that injected venom into their circulatory system. The venom has an
inhibitory effect on the reuptake of acetylcholine from the synaptic cleft. Explain how the mouse’s body would
respond to the venom as well as the venoms effect at the cellular level.
A patient has been exposed to the organophosphate pesticide malathion,which inactivates acetylcholinesterase. Which of the following symptoms would you predict: blurring of vision, excess tear formation, frequent or involuntary urination, pallor (pale skin), muscle twitching, orcramps? Would atropine be an effective drug to treat the symptoms?(See Clinical Impact 16.2 for the action of atropine.) Explain.
Chapter 48 Solutions
Campbell Biology: Australian And New Zealand Edition + Mastering Biology With Etext
Ch. 48.1 - Prob. 1CCCh. 48.1 - Describe the basic pathway of information flow...Ch. 48.1 - WHAT IF? How might increased branching of an axon...Ch. 48.2 - Under what circumstances could ions flow through...Ch. 48.2 - WHAT IF? Suppose a cell's membrane potential...Ch. 48.2 - MAKE CONNECTiONS Review Figure 7.10, which...Ch. 48.3 - How do action potentials and graded potentials...Ch. 48.3 - In multiple sclerosis (from the Greek skleros,...Ch. 48.3 - How do both negative and positive feedback...Ch. 48.3 - WHAT IF? Suppose a mutation caused gated sodium...
Ch. 48.4 - Prob. 1CCCh. 48.4 - Some pesticides inhibit acetylcholinesterase, the...Ch. 48.4 - Prob. 3CCCh. 48 - How would severing an axon affect the flow of...Ch. 48 - Suppose you placed an isolated neuron in a...Ch. 48 - Prob. 48.3CRCh. 48 - Prob. 48.4CRCh. 48 - Level 1: Knowledge/Comprehension 1. What happens...Ch. 48 - Level 1: Knowledge/Comprehension 1. What happens...Ch. 48 - Where are neurotransmitter receptors located? (A)...Ch. 48 - Why are action potentials usually conducted in one...Ch. 48 - Which of the following is the most direct result...Ch. 48 - Suppose a particular neurotransmitter causes an...Ch. 48 - WHAT IF? Ouabain, a plant substance used in some...Ch. 48 - Prob. 8TYUCh. 48 - DRAW IT Suppose a researcher inserts a pair of...Ch. 48 - EVOLUTION CONNECTION An action potential is an...Ch. 48 - Prob. 11TYUCh. 48 - WRITE ABOUT A THEME: ORGANIZATION In a short essay...Ch. 48 - Prob. 13TYU
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following structures has activity like acetylcholine? HyC H-C HC NMeg NMey D]arrow_forwardOne treatment for myasthenia gravis is a medication that blocks the activity of acetylcholinesterase. Suggest why this might be a successful treatment.arrow_forwardWhat is the difference between inactivate and closed Na+ channels?Explain how a salty flavor is transduced into an action potential. Describe each step in an action potentialarrow_forward
- What would happen to an insect if you treated an insect with a chemical that inhibits acetylcholinesterase? 1) K+ channels get stuck open and the neuron stays perminantly hyperpolarized 2) Acetylcholine would continue to activiate Ca++ channels until death by exhaustion 3) Acetylcholine would continue to activiate Na+ channels until death by exhaustionarrow_forwardWhen the neurotransmitter acetylcholine (ACh) binds the acetylcholine receptor (a GPCR) on muscle cells, it causes them to contract. ZIGGY, a chemical analog of ACh, also binds to the same acetylcholine receptor on muscle cells, but instead causes the muscle cells to relax. For this reason, it is sometimes prescribed as a muscle relaxer. Explain in 3-4 sentences how ZIGGY could cause muscle relaxation. How can both ZIGGY and ACh bind the same GPCR? And then how can they have different effects on the cells, despite binding to the same receptor on the same cells?arrow_forwardDendrotoxins, produced by the mamba snakes (Dendroaspis), are inhibitors of the voltage-gated K+ channels. What phase of the action potential would this toxin affect? How would it affect ion permeability during this phase? How would ion movement be affected?arrow_forward
- View the University of Michigan WebScope (http://openstaxcollege.org/l/nervefiber) to see an electron micrograph of a cross-section of a myelinated nerve fiber. The axon contains microtubules and neurofilaments that are bounded by a plasma membrane known as the axolemma. Outside the plasma membrane of the axon is the myelin sheath, which is composed of the tightly wrapped plasma membrane of a Schwann cell. What aspects of the cells in this image react with the stain to make them a deep, dark, black color, such as the multiple layers that are the myelin sheath?arrow_forwardUnder anesthesia, acetylcholinesterase inhibitors can be given in combination with blockade of muscarinic receptors. Explain the purpose of the two treatments.arrow_forwardConsider the following three diagrams of a nerve cell membrane. They show resting potential, depolarization, and hyperpolarization. Figure out which one is which, then draw them in the order they occur in a cell that undergoes an action potential outside + Na* inside K* Na* Nat K Nat K Na potential: -80 mV outside + Na K* Na* inside Na+ K Nat Na* K+ potential: +30 mV outside Na Na Na Na* K+ inside K* Na* Kt potential: -70 mVarrow_forward
- Below is a figure from a 2015 paper that characterizes the effect of venom from the spider Selenocosmia hainana on voltage-gated sodium channels. According to the I-V curve (current-voltage curve) in Figure panel B, what is the effect of the venom on voltage-gated sodium channels? Current is on the y-axis and voltage is on the x-axis during an action potential. The figure legend denotes the concentration of the venom being applied. A C rHNTX-IV (10 μM) -rHNTX-IV (100 nM) Control Control 5 nA 10 ms r 5 nA 10 ms rHNTX- IV (10 μM) B D -80 -80 -60 -60 A -40 -40 V (mv) -20 V(mv) -20 be TOLF 2-6 I (NA) -8 ON -12 10 -12 -14 -8 -10 (NA) Control 100 nM — 10 μΜ 40 -Control -- 10 μM 40arrow_forwardIn a disease called GB syndrome, the immune system attacks and degrades the myelin sheath of PNS axons. What is a possible effect that this will have on nerve impulse and muscle function.arrow_forwardAre these true or false? Acetylcholine molecules are actively transported from the axon to their receptors on the muscle membrane by special transport proteins. Receptors on the post-synaptic cell membrane that bind the acetylcholine are voltage-gated channels (channels that open in response to a change in the electrical charge of the membrane). When a muscle cell is not contracting its cell membrane is negative on the inner surface. The effect of a neurotransmitter on the muscle cell membrane is to modify its ion permeability properties temporarily. During depolarization, a small region of the muscle cell's membrane becomes less negative on the inside." Both sodium and potassium are more concentrated in the extracellular fluid than the intracellular fluid. After an action potential passes over a region of the sarcolemma the region remains positively charged throughout the entire muscle contraction. An increase in the calcium ion level in the cytosol causes thin filaments to begin…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Basic Clinical Lab Competencies for Respiratory C...NursingISBN:9781285244662Author:WhitePublisher:Cengage
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Medical Terminology for Health Professions, Spira...Health & NutritionISBN:9781305634350Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. SchroederPublisher:Cengage Learning
Basic Clinical Lab Competencies for Respiratory C...
Nursing
ISBN:9781285244662
Author:White
Publisher:Cengage
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Medical Terminology for Health Professions, Spira...
Health & Nutrition
ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Cengage Learning
The Sensorimotor System and Human Reflexes; Author: Professor Dave Explains;https://www.youtube.com/watch?v=M0PEXquyhA4;License: Standard youtube license