EBK BIOLOGY
4th Edition
ISBN: 8220102797376
Author: BROOKER
Publisher: YUZU
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Chapter 5, Problem 1COQ
Summary Introduction
To determine: The reason for the proteins inside the plasma membrane is the target of various medicines.
Introduction: Various types of important roles are performed by the proteins of the plasma membrane. These proteins are very important for the normal
Summary Introduction
To determine: The way by which it can be experimentally proved that a specific membrane protein act as the target of a particular drug.
Introduction: Various types of important roles are performed by the proteins of the plasma membrane. These proteins are very important for the normal metabolic functions of the living organisms.
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You are working on a team that is designing a new drug. For this drug to work, it must enter the cytoplasm of specific
target cells.
Which of the following would be a factor that determines whether the molecule selectively enters the target cells?
O the phospholipid composition of the target cells' plasma membrane
O the nonpolar, hydrophobic nature of the drug molecule
the similarity of the drug molecule to other molecules that are transported into the target cells
the concentration of the drug molecule that is transported in the blood
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Dr Renko studied diffusion of tracer molecules to study paracellular diffusion across an epithelial monolayer of Caco-2 cells. The tracers were fluorescently labelled dextran molecules of different molecular weight. She is screening various drugs to determine whether they affect the cells in any way. Which drugs are most likely to change paracellular diffusion?
a.) Drugs that modify microvilli are the most likely to change paracellular diffusion
b.) Drugs that modify gap junctions are the most likely to change paracellular diffusion
c.) Drugs that modify with aquaporins are the most likely to change paracellular diffusion
d.) Drugs that modify tight junctions are the most likely to change paracellular diffusion
Which of the following statements are correct about how the complex biological matrix of the cell may affect protein folding, stability and function (select all that appy)?
A.
ATP tends to "bounce" along the surfaces of many proteins without forming a stable complex
B.
Proteins make up approximately 30% of the total volume of the cytoplasm in a typical cell
C.
Compettition between drug molecules and metabolites in the cytoplasm may cause unexpected drug side effects not seen with individual proteins in solution.
D.
Large protein complexes move faster through the cytoplasm than small metabolites.
E.
Complex intercations between proteins in the cell may significantly destabilize a protein compared to the isolated protein in water
Chapter 5 Solutions
EBK BIOLOGY
Ch. 5.1 - Prob. 1CCCh. 5.2 - Prob. 1CCCh. 5.2 - Prob. 2CCCh. 5.2 - Prob. 1BCCh. 5.3 - Prob. 1CCCh. 5.3 - Prob. 2CCCh. 5.4 - Prob. 1BCCh. 5.4 - Which molecule would you expect to pass through a...Ch. 5.4 - Prob. 2BCCh. 5.4 - Lets suppose the inside of a cell has a solute...
Ch. 5.5 - What is the purpose of gating?Ch. 5.5 - Prob. 1EQCh. 5.5 - Prob. 2EQCh. 5.5 - Prob. 3EQCh. 5.5 - Prob. 2CCCh. 5.6 - What is the function of the protein coat?Ch. 5 - Prob. 1TYCh. 5 - Which of the following events can never be...Ch. 5 - Lets suppose an insect, which doesnt maintain a...Ch. 5 - Prob. 4TYCh. 5 - Prob. 5TYCh. 5 - Prob. 6TYCh. 5 - Prob. 7TYCh. 5 - Prob. 8TYCh. 5 - Prob. 9TYCh. 5 - Large particles or large volumes of fluid can be...Ch. 5 - With your textbook closed, draw and describe the...Ch. 5 - Prob. 2CQCh. 5 - Prob. 3CQCh. 5 - Prob. 1COQCh. 5 - With regard to bringing solutes into the cell...
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- Moat drug act by altering the various body control systems.Name the binding site located on the surface of the cell to which drug binds to show its action with example of such drugs. Mention 2 drugs that act by inhibiting transport.arrow_forward8) Indicate which of the five major types of membrane protein (adhesion, enzymatic, recognition, receptor, and transport) is most likely to be involved in each of the situations described below: a) An oncologist wants to study the cells from a certain tumour that has been surgically removed from a patient. However, she must first treat the tumour with a solution affects a membrane protein on the tumour cells. Because of the effect of the solution on the membrane protein, the tumour tissue falls apart into individual cells. Type of membrane protein: b) Farmer Jebediah wakes up in the morning and makes himself an extra-strong coffee. The caffeine in the coffee attaches to a protein in the plasma membrane of his neurons, inducing a signal transduction cascade and causing Farmer Jebediah to be more alert Type of membrane protein:arrow_forwardFill in the blanks please.arrow_forward
- Cell adhesion molecules (CAMs) can form cis and trans interactions with other CAM molecules. True or Falsearrow_forwardOsmosis Practice Activity Osmosis is the diffusion of water from an area of high concentration to an area of low concentration. Only water moves in osmosis! The diagrams below show the concentration of water and salt inside the cell and the concentration of water and salt surrounding the cell. Complete the sentences below by comparing the concentration of the water inside the cell and the concentration outside the cell. 1. a. Water will flow the cell, out of the cell, in both directions). (into 5% NaCl 95% H20 95% NaCI 5% H20 b. The cell will (shrink, burst, stay the same). a. Water will flow (into the cell. 2. 5% NaCl out of the cell, in both directions). 5% NaCl 95% H20 95% H20 b. The cell will (shrink, burst, stay the same).arrow_forwardGap junctions and tunneling nanotubes are two distinct types of direct intracellular communication. In comparing and contrasting gap junctions and tunneling nanotubes, which of the following statements is true? gap junctions provide a portal for small molecules, proteins and small organelles to move from cell to cell, tunneling nanotubes only permit small molecules to pass between cells typically, there are only two gap junctions that exist between adjacent cells that are communicating via this mechanism; on the other hand, there are many tunneling nanotubes between communicating cells both gap junctions and tunneling nanotubes can pass small molecules between cells none of the above is truearrow_forward
- To improve the efficiency of axonal transport, bundles of similar proteins are packaged and transported together instead of individually. This is described by the: Transport Efficiency Hypothesis Microtubule Hypothesis Theory of Relativity Structural Hypothesisarrow_forward5. Which of the following is NOT true about channel and carrier proteins? a) Carriers never form a direct opening between inside and outside the cell. b) Channels generally transport material faster than carriers. c) Only carriers are used for selective transport of materials d) All of the above are true about channel and carrier proteins. 6. If it can cross a membrane, a solute will move from a hyposmotic/hyperosmotic (circle or highlight the correct one) solution to a hyposmotic/hyperosmotic (circle or highlight the correct one) solution. 7. Water always moves from a hyposmotic/hyperosmotic (circle or highlight the correct one) solution to a hyposmotic/hyperosmotic (circle or highlight the correct one) solution.arrow_forwardSimilarly, what will be the effect on membrane potential if Cl- ions move into a cell?arrow_forward
- ABC transporters are: a. An example of active transport with activity in multi-drug resistance. b. An example of passive-mediated transport with activity in multi-drug resistance. c. An example of an ion channel that binds ATP for effective transport. d. An example of a pump involved in Ca2+ transport. e. An example of an antiporter.arrow_forwardPlease answer both questions: 1) The sodium-potassium pump: a) equalizes the charge distribution across the cell membrane. b) transports K+ into the cell where it is in high concentration. c) requires very little energy expenditure on the part of nerve cells. d) establishes concentration gradients across the cell membrane. 2) Membrane potentials are always expressed comparing the inside of the cell relative to the outside of the cell. The resting membrane potential is -70 mV because the inside of the cell accumulates ions with negative charges. a) True b) Falsearrow_forwardHow can we find the resistance of a cell-membrane?arrow_forward
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