A treatment trial is proposed to test the efficacy of vitamin E as a preventive agent for cancer. One problem with such a study is how to assess compliance among participants. A small pilot study is undertaken to establish criteria for compliance with the proposed study agents. In this study, 10 patients are given 400 IU/day of vitamin E and 10 patients are given similar-sized placebo capsules over a 3-month period. Their serum vitamin E levels are measured before and after the 3-month period, and the change (3-month – baseline) is shown in Table 5.2.
Table 5.2 Change in serum vitamin E (mg/dL) in pilot study
Suppose a change of 0.30 mg/dL in serum levels is proposed as a test criterion for compliance; that is, a patient who shows a change of ≥ 0.30 mg/dL is considered a compliant vitamin E taker. If normality is assumed, what percentage of the vitamin E group would be expected to show a change of at least 0.30 mg/dL?
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