Concept explainers
To determine: Whether the function of Ca2+ as a secondary messenger would be affected if a drug blocks all Ca2+ channels that are linked to G-proteins.
Introduction: A messenger includes proteins, hormones, or any other molecules that bind to a specific receptor and induces a conformational change in the structure of the receptor. Messengers are of two types namely, primary or secondary messengers. G-protein–coupled receptor (GPCR) is seven-transmembrane extracellular receptors present in the cell membrane. G-proteins are generally bound to plasma membrane receptors on the cytosolic surface and they are made of three subunits, namely alpha, beta, and gamma subunits.
To determine: The reason why secondary messenger function of Ca2+ is not affected when all Ca2+ channels linked to G-proteins are blocked.
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Vander's Human Physiology
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