Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
6th Edition
ISBN: 9780815344322
Author: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 5, Problem 6P
Summary Introduction

To explain:  The reason that there is much variation in the frequencies of mutant cells in different cultures assuming that the rate of mutation is constant.

Introduction: During DNA replication, each of the original DNA strands serves as a template for the formation of entire new strand. DNA polymerase synthesize DNA strand by adding deoxyribonucleoside triphosphates on single strand DNA template. To maintain the genetic stability, the accuracy of the DNA replication is must, but also there is another mechanism called DNA repair mechanism that is important to repair the accidental lesions that DNA continually suffers. This eliminates the most of the changes, thereby minimizes the mutation rate.

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