Principles of Human Physiology - Mastering A&P
Principles of Human Physiology - Mastering A&P
6th Edition
ISBN: 9780134298900
Author: STANFIELD
Publisher: PEARSON
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Chapter 5.2, Problem 3CTQ
Summary Introduction

To write:

Disadvantages and advantages of using COX-2 inhibitors, rather than NSAIDs, to treat pain.

Introduction:

NSAIDs are non-steroidal anti-inflammatory drugs. They are the traditional doses for pain and fever. They are the analgesics and work on the cyclooxygenases. Cyclooxygenases are of two types, cyclooxygenase-2(COX-2) and cyclooxygenase-1 (COX-1). NSAIDs work by inhibiting the secretion of prostaglandin. COX-1 is placed in the stomach lining and COX-2 is responsible for the secretion of proinflammatory cytokinin and prostaglandins that mediate inflammatory responses and pain. So, the work of NSAIDs is to bind to the active site of the enzyme and blocking its functioning.

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Principles of Human Physiology - Mastering A&P

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