Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
6th Edition
ISBN: 9780815345244
Author: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 6, Problem 1P
Summary Introduction

To examine:  Whether the statement “the consequences of errors in transcription are less severe than those of errors in DNA replication” is true or false.

Introduction:

DNA is known as the blueprint of life as it controls gene expression. It directs messenger RNA (mRNA) synthesis in the cell through transcription. During formation of mRNA, each letter in the gene sequence is copied which codes for a particular protein. The genetic information in mRNA is translated for the synthesis of polypeptide chains. This is known as gene expression.

Expert Solution & Answer
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Answer to Problem 1P

Correct answer: The statement is true.

Explanation of Solution

Every time a cell divides and its DNA replicates, it has to copy and transmit the exact same sequence of billions of nucleotides to its daughter cells. Despite the high fidelity of the process, errors occur. DNA consists of basic genetic information that code for protein synthesis. If any error occurs in coding DNA nucleotide sequence, it would be copied to mRNA copies. As a result, the synthesized proteins would be truncated and non-functional. In contrast, a mistake in transcription process causes an error in both mRNA sequence and the polypeptide synthesized from that sequence. The other proteins synthesized would not be changed. Thus, the consequences caused due to errors in nucleotide sequence during DNA replication are more severe as compared to those occurring during transcription.

Hence, the statement is true.

Conclusion
The errors in DNA replication are worse than the errors in transcription.

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