IMMUNE SYSTEM-W/CASE STUDIES (2 BOOKS)
4th Edition
ISBN: 9780393698237
Author: PARHAM
Publisher: NORTON
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Question
Chapter 6, Problem 1Q
Summary Introduction
To match:
The term from the column A to the correct description in the column B.
Introduction:
B-cellsare a type of white blood cell. It is a subtype of the lymphocyte. They play arole in the humoral immunity by secreting antibodies. Humoral immunity is a component of the adaptive immune system.
Expert Solution & Answer
Answer to Problem 1Q
The table below represents the correct match from the Column A to Column B.
Column A | Column B |
a. Immature B-cell | 4. μ heavy chain plus λ or κ light chains on cell surface |
b. Small pre-B-cell | 1. V-J rearranging |
c. Large pre-B-cell | 5. VDJ rearranged but light-chain gene in germline configuration |
d. Stem cell | 2. germline configuration of heavy- and light-chain genes |
e. Early pro-B-cell | 6. D-J rearranging. |
f. Late pro-B cell | 3. V-DJ rearranging |
Explanation of Solution
- Immature B-cells are more sensitive to antigen binding. If they bind with self-antigen in the bone marrow, they usually die. They bear heavy chain and light chain on their cell surface. Hence, this can be correctly matched with 4.
- In the process of proliferation of cells, small pre-B cell shows no more division. These undergo the rearrangement by V-J joining on one of the L-chain chromosomes. Hence, it can be correctly matched with 1.
- The large pre-B-cell receptors are usually a heterodimer is made up of an immunoglobulin heavy-chain molecule represented as IgH. It is associated covalently with an immunoglobulin light chain-like molecule known as the surrogate light chain. Hence, it can be correctly matched with 5.
- Stem cells can further differentiate from other types of cells. These can also divide in self-regeneration to yield the more similar type of stem cells. Hence, it can be correctly matched with 2.
- The cells generally undergo D-J linking on the H-chain chromosome. When these become early pro-B type cellsthey start to express CD45 and MHC Class-II molecules. Late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 6.
- CD19 usually help in the development of early and late B cell. The late pro-B cell stage is completed by the linking of a V-segment to D-JH complex. Hence, it can be correctly matched with 3.
Conclusion
The table below represents the correct match from Column A to Column B.
Column A | Column B |
a. Immature B-cell | 4. μ heavy chain plus λ or κ light chains on cell surface |
b. Small pre-B-cell | 1. V-J rearranging |
c. Large pre-B-cells | 5. VDJ rearranged but light-chain gene in germline configuration |
d. Stem cell | 2. germline configuration of heavy- and light-chain genes |
e. Early pro-B-cell | 6. D-J rearranging. |
f. Late pro-B cell | 3. V-DJ rearranging |
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Chapter 6 Solutions
IMMUNE SYSTEM-W/CASE STUDIES (2 BOOKS)
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