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Concept explainers
Interpretation:
“Fighting Alzheimer’s disease by boosting the stability of the retromer is based on the hypothesis that most of the APP is cleaved in the endosome to release β amyloid”. Whether most of the APPs are cleaved on the cell membrane or not (as previously thought) is to be discussed.
Concept Information:
A neurodegenerative disease that has been mainly seen in old people that causes symptoms such as loss of memory, delusions and even changes in personality is known as Alzheimer’s disease. The brains of the individuals suffering from it shrink and also lose certain folds of the lobes.
A retromer is the complex used for shuttling proteins from the endosomes to the Golgi apparatus inside a cell.
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Chapter 7 Solutions
Owlv2,1 Term Printed Access Card For Campbell/farrell/mcdougal's Biochemistry, 9th
- REFLECT AND APPLY List three molecular changes that take place in the processing of eukaryotic mRNA.arrow_forwardREFLECT AND APPLY Would you expect mRNA or rRNA to be degraded more quickly in the cell? Why?arrow_forwardREFLECT AND APPLY Why is a trimming process important in converting precursors of tRNA and rRNA to the active forms?arrow_forward
- REFLECT AND APPLY You are in the process of determining the amino acid sequence of a protein and must reconcile contradictory results. In one trial, you determine a sequence with glycine as the N-terminal amino acid and asparagine as the C-terminal amino acid. In another trial, your results indicate phenylalanine as the N-terminal amino acid and alanine as the C-terminal amino acid. How do you reconcile this apparent contradiction?arrow_forwardREFLECT AND APPLY Explain why a 50S ribosomal subunit and a 30S ribosomal subunit combine to form a 70S subunit, instead of an 80S subunit.arrow_forwardREFLECT AND APPLY Is the following statement true or false? Why? The flow of genetic information in the cell is always DNARNAprotein.arrow_forward
- REFLECT AND APPLY You are studying with a friend who says that the hydrogen-bonded portions of tRNA play no important role in its function. What is your reply?arrow_forwardREFLECT AND APPLY List three mechanisms that relax the twisting stress in helical DNA molecules.arrow_forwardREFLECT AND APPLY Outline a mechanism by which RNA can catalyze its own self-splicing.arrow_forward
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning
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