Biology Now with Physiology (Second Edition)
Biology Now with Physiology (Second Edition)
2nd Edition
ISBN: 9780393631791
Author: Anne Houtman, Megan Scudellari, Cindy Malone
Publisher: W. W. Norton & Company
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Chapter 8, Problem 8TQ
Summary Introduction

Sickle-cell disease is a chronic, inherited anemia and it is caused by a mutation in the hemoglobin protein coding gene. Hemoglobin carries oxygen and the gene coding for hemoglobin protein is located on the chromosome 11. The sickle-cell disease is an autosomal recessive genetic disorder, in which red blood cells (RBC) sickle, plugging small blood vessels. The normal hemoglobin allele (H) dominates the sickle cell allele (h). The recessive allele is responsible for the sickle-cell disease. An individual carrying two recessive alleles (hh) can result in sickle-cell disease. The carrier contains one dominant (H) allele and one recessive allele (h).

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