A common symptom of otitis media in young children is the prolonged presence of fluid in the middle ear, known as middle-ear effusion. The presence of fluid may result in temporary hearing loss and interfere with normal learning skills in the first 2 years of life. One hypothesis is that babies who are breastfed for at least 1 month build up some immunity against the effects of the infection and have less prolonged effusion than do bottle-fed babies. A small study of 24 pairs of babies is set up, in which the babies are matched on a one-to-one basis according to age, sex, socioeconomic status, and type of medications taken. One member of the matched pair is a breastfed baby, and the other member is a bottle-fed baby. The outcome variable is the duration of middle-ear effusion after the first episode of otitis media. The results are given in Table 9.11.
Table 9.11 Duration of middle-ear effusion in breastfed and bottle-fed babies
Why might a nonparametric test be useful in testing the hypotheses?
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Fundamentals of Biostatistics
- In an observational study, it was noticed that people that eat more chocolate tend to have better blood flow than the general population. Researchers wonder whether the improved blood flow might be caused by flavanols (a molecule found in many foods). Dark chocolate contains a high concentration of flavanols, but milk chocolate contains a much lower concentration. How could the researchers design an experiment to determine the effects of flavanol on blood flow from the different types of chocolate?arrow_forwardResearchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.05) Type II Diabetes No Type II Diabetes Total Investigational Drug 45 19 64 Best standard of Care 70 123 193 Total 115 142 257 Ho? Ha? X2 value? x2 critical? Conclusion?arrow_forwardResearchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.01) Type II Diabetes No Type II Diabetes Total Investigational Drug 45 32 77 Best standard of Care 35 50 85 Total 80 82 162 Based on this information complete the hypothesis steps for Chi-Squared below:…arrow_forward
- Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.05) Type II Diabetes No Type II Diabetes Total Investigational Drug 45 19 64 Best standard of Care 70 123 193 Total 115 142 257 Ho? Ha? x2 value? X2 critical? p value? conclusion?arrow_forwardA common symptom of otitis media in young children is the prolonged presence of fluid in the middle ear, known as middle-ear effusion. The presence of fluid may result in temporary hearing loss and interfere with normal learning skills in the first 2 years of life. One hypothesis is that babies who are breastfed for at least 1 month build up some immunityagainst the effects of the infection and have less prolonged effusion than do bottle-fed babies. A small study of 24 pairs of babies is set up, in which the babies are matched on a one-to-one basis according to age, sex, socioeconomic status, and type of medications taken. One member of the matched pair is a breastfed baby, and the other member is a bottle-fed baby. The outcome variable is the duration of middle-ear effusion after the first episode of otitis media. The results are given in Table 9.11. A) What hypotheses are being tested here? B) Why might a nonparametric test be useful in testing the hypotheses? C) Which nonparametric…arrow_forwardThere have been many studies recently concerning coffee drinking and cholesterol level. While it is known that several coffee-bean components can elevate blood cholesterol level, it is thought that a new type of paper coffee filter may reduce the presence of some of these components in coffee. The effect of the new filter on cholesterol level will be studied over a 10-week period using 300 nonsmokers who each drink 4 cups of caffeinated coffee per day. Each of these 300 participants will be assigned to one of two groups: the experimental group, who will only drink coffee that has been made with the new filter, or the control group, who will only drink coffee that has been made with the standard filter. Each participant’s cholesterol level will be measured at the beginning and at the end of the study. Describe an appropriate method for assigning the subjects to the two groups so that each group will have an equal number of subjects. In this study, the researchers chose to include a…arrow_forward
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