Huntingtin

The Ethical proprietaries of CRISPR-Cas L. DEDROOG Bachelor in de Farmaceutische en Biologische Laboratoriumtechnologie OPO: Beroepsethiek Academiejaar 2016-2017 UC Leuven – Limburg Gezondheid en Welzijn • Campus Gasthuisberg Herestraat 49 • 3000 Leuven 1. Introduction Over the past decade there has been an enormous increase in high efficient techniques for studying the cell on a molecular level [1]. These techniques are responsible for a better understanding of the human body and the invention

time-span rather than adult-onset that predicts only 15-20 years. The pathology of Huntington’s is a progressive, fatal, neurodegenerative disorder that is the result of an inherited autosomal dominant trait. Huntington’s is caused by an expanded huntingtin (HTT) gene that is located in the arm of chromosome 4, that encodes an abnormally long polyglutamine repeat protein. This mutation that was found about 20 years ago, we still do not have further knowledge on the mechanism in which the abnormally

Dementia Dementia is not a specific disease, it is the term that describes a group of symptoms. It is the decline in memory, other thinking and social skills, which is severe enough to reduce a person's ability to perform their everyday activities (Dementia 2018). Daily activities such as use of language for communication, the ability to focus and pay attention to their environment, their reasoning and judgmental skills. Dementia is mostly common among older adults, age 65 is a good age for people

Proteins play a part in every cellular activity and must fold into proper three dimensional configurations, or native state, to execute their intended functions. Proteomic stressors such as chemical exposure or elevated temperature can inhibit protein folding upsetting protein homeostasis and resulting in cell death and human disease (Broadley 2009). Excessive protein misfolding can lead to amyloid fibrillar aggregates which deposit around brain neurons contributing to the development or progression

Other type of dementia can be coupled with a rare hereditary disorder known as CADASIL which stands for cerebral autosomal dominant ateriopathy with subcortical infarct and leukoencephalopathy. This disorder is linked to abnormalities of a specific gene, Notch3 located on chromosome 19. The first symptoms arise at the age of 20 or 35 or 40 and the individuals often die at the age of 65. Researchers are still working to find out the exact cause of CADASIL. Other causes of vascular dementia include

Large animal models for neurodegenerative diseases Numerous human genetic disorders, such as neurodegenerative diseases, occur because of genetic mutations in human cells. New genome editing tools – as of 2014 - such as transcription activator-like endonucleases (TALENs) or CRISPR/Cas9 further ease the precise generation of non-human primates (NHP) models for human diseases. Several of these NHP models displayed clinical manifestations like those of human disorders, in comparison with rodent models

INDEX Preface I- Introduction - Brain Structure and Basic Functions II- Memory - Introduction - Improve your Memory - Memory Disorders III- concentration/focus - Introduction - Improve concentration/focus - Concentration/Focus Disorders IV- Brain & Nutrition V- Brain & Sleep VI- Brain & Exercise VII- Brain & Social Life VIII- Negatives for brain health - Stress - Alcohol - Smoking - Drug Addiction - Traumatic Brain Injury - Cerebrovascular Disease   Preface The brain is the control center of

Section One: Biological concepts/ideas/processes. A popular socio-scientific issue discussed in our society recently is the use of In-vitro Fertilisation (IVF) and pre-implantation Genetic Diagnosis (PGD).1 In-vitro Fertilisation (IVF) was established to treat infertility caused by blocked or damaged fallopian tubes.1 IVF is usually used to treat a variety of infertility problems but it can also screen for any genetic disorders.1 There are six stages in IVF, ovarian stimulation, egg collection,

Abstract This analysis of degenerative diseases covers four main diseases in today’s world, including: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Dementia. Alzheimer’s is a degenerative form of dementia that attacks neurons causing the total or partial loss of memory, thinking abilities, language skills, and basic behaviors. Parkinson’s is a progressive disease that targets the central nervous system. Generally the disease will cause tremors, loss of coordination, paralysis

Since the discovery in 1928 via the Griffith experiment (an experiment dealing with bacterial transformation) that DNA carried genetic information, many important discoveries have been made regarding the human genome and its extent in the determination of phenotypic traits. Not least of these is the discovery and study of genetic disorders, or diseases caused by abnormalities within the genes. Disorders of this nature can be caused by a variety of factors. Some diseases such as Huntington's disease