Vincristine

Vincristine, also known as VCR, is a chemical found in the Vinka Alkaloid Class, and each member of this class can be obtained from the Madagascar Periwinkle plant. They can either naturally occur or be synthetically derived from the pink periwinkle plant Catharanthus roseus. Vincristine is most commonly used in chemotherapy, and can treat cancers ranging from “leukemia, rhabdomyosarcoma, neurobastoma, and other Lymphoma cancers,” as well as Hodgkins Disease and Wilm’s tumor. Although Vincrisitine

biosynthetic capability”(Lokanatha M. K. Prof). Natural products play a very pivotal role in the identification of compounds that are essential in the treatment of many devastating ailments such as cancer. Vincristine is an example of a lead anti-cancer compound that is derived from plant. Vincristine is from a class of vinca alkaloid that is derived from the plant Catharanthus Roseus. Catharanthus Roseus is also known as periwinkle and is popularly found in Madagascar. It is used for decorative purposes

roseus act antagonistically to cancer cells, the next step was to elucidate the precise method by which the alkaloids function, both in plants and in humans. Physically, vincristine and vinblastine have very nearly the same structure; the first has formyl group on one part of the molecule and the second has a methyl group (Cragg et al., 1994). Since both are categorized as dimeric monoterpenoid indole alkaloids (dMIAs), they

Assessment tools It has been established that there are at present no adequate forms of preventing CIPN (Cavaletti, 2014). Additionally, CIPN is often under-rated and under-reported particularly as patients do not like to miss treatments (Stubblefield et al., 2009). Therefore, comprehensive evaluations using standardized and sensitive assessment tools to prevent severe neurotoxicity are a critical step for early intervention. According to Stubblefield et al. (2012), it is essential a baseline assessment

SECTION TWO 1. Which antibacterial agent(s) would be effective in the therapy of Mr BT’s urinary tract infection? Cephalexin and Gentamicin would be effective since they are equally sensitive to the pseudomonas aeruginosa microbe which implies they will kill the microbe and work against the bacteria. 2. State the mechanisms of action of each of these agents. Cephalexin, is a beta-lactam antibiotic. The antibiotic binds to specific penicillin-binding proteins positioned inside the bacterial

Leukaemia is a malignancy of bone marrow in which there is unregulated growth of white blood cells in the bone marrow. It is state when alterations occur in the normal regulatory process which results in uncontrolled production of stem cells in the bone marrow. Acute leukaemia is a condition of malignancy most commonly diagnosed in children. Acute leukaemia accounts for 25% of cancers diagnosed in children and adolescents aged 1-19 years which accounts for approximately 3000 new cases in the US

over three thousand plants found can help the fight against cancer. Seventy percent of these plants are found in the rainforest. Periwinkle is a very essential plant that produces the drug Vincristine that is the most powerful cancer-fighting drug that has been discovered as of today. Scientists say, "Vincristine is used as a part of MOPP chemotherapy regimen, and has helped increase the rate of remission in acute childhood leukemia from twenty percent to ninety percent.." The periwinkle plant is only

Systemic chemotherapy continues to be the treatment of choice for most patients. Most dogs treated for lymphoma will receive a multidrug chemotherapy CHOP regimen consisting of cyclophosphamide, vincristine, prednisone, and doxorubicin. During treatment for canine lymphoma, the drug L-asparaginase (L-asp) is supplemented in order to catalyze the cleavage of asparagine to ammonia and aspartate. The level of asparagine is depleted from circulating blood by use of L-asp, diminishing its availability

participants were children recruited between September 1991 and November 1993. Roberts et al., counted with a total of 74 participants for the experiment. The type of remission used in this study was based on a four weeks treatment. Participants intake vincristine, prednisone, and asparaginase. In addition, the main finding in this experiment was that 15 participants were at standard risk for getting sick again after a great improvement. 7 participants were at intermediate risk, and 3 participants were at

1. Identify at least three times during this video that the error could have been prevented. First off, the error could’ve been prevented by the pharmacist. He could’ve refused to fill the medications because he knew what the doctor was asking for wasn’t a normal request. Next, since the doctor scheduled to complete the intrethecal had a family emergency the procedure could’ve been rescheduled until a later date. Lastly, the doctor should’ve never taken the medication from pharmacy and then later