Exam 4A-keys-2024-1

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School

Le Cordon Bleu College Of Culinary Arts *

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Course

406

Subject

Biology

Date

May 19, 2024

Type

pdf

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Uploaded by MateElementPelican13

1 DO NOT BEGIN THIS EXAM UNTIL INSTRUCTED TO DO SO IMPORTANT!!! DO THIS FIRST!! Properly Fill in Test Version (A) and Student ID # on your Scantron form. • There are 28 multiple choice questions on this exam. • All questions have ONE and only ONE correct answer. • All questions are worth the same number of points. • No points are subtracted for incorrect answers (you should guess). • No points are awarded for a question if more than one answer is given. • No use of any electronics or notes is permitted during the exam. We will not accept any exams before 9:15. Remain seated until then. The exam ends at 10:20. Students handing in Late Exams will be penalized. ––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

3 1. Which ONE of the following fatty acids CAN be made from Oleate – 18:1( D 9) – in HUMANS ? Humans have desaturases that can create cis-double bonds at Δ4, Δ5, Δ6, and Δ9. A. 20:3 ( D 6, 10, 11) B. 22:3 ( D 5, 10, 13) C. 24:3 ( D 4, 14, 15) D. 26:4 ( D 4, 5, 11, 14) E. All of the above fatty acids CANNOT be made from Oleate in humans. 2. Based on what you learned in BIOC406, which ONE of the following happens in the ER membrane? A. Synthesis of palmitoyl-carnitine by CAT-1 (Carnitine Acyl-transferase-1) B. Hydrolysis of fat by Lipoprotein Lipase C. Production of cAMP by Adenylate Cyclase (AC) D. Cholesterol binding to the sterol-sensing domain of SCAP E. Synthesis of malonyl-CoA by ACC (Acetyl-CoA Carboxylase) 3. We excrete extra nitrogen/NH3 in various tissues by converting it to Urea in the liver. Which of the following is used to excrete extra nitrogen/NH 3 in the muscle? I. Transaminases II. Glutamate Dehydrogenase III. Arginase IV. Carbamoyl Phosphate Synthetase-II (CPS-II) A. I and III only B. II and IV only C. I, II, and III only D. I, III, and IV only E. I, II, III, and IV 4. Which ONE of the following is NOT likely to cause hyperglycemia (elevation of blood glucose levels)? Choose the best answer. A. A mutation in the Insulin receptor that decreases the affinity for Insulin. B. A mutation in Glut4 that increases the Km for glucose. C. A mutation in Glut2 that decreases the affinity for glucose. D. A mutation in Glucokinase that increases the Km for glucose. E. A mutation in the Insulin receptor that increases its kinase activity.

4 5. Which ONE of the following proteins does NOT directly bind to DNA? If ALL of these proteins directly bind to DNA, choose answer E. A. Topoisomerase I B. Eukaryotic general transcription factors (GTFs) C. Eukaryotic transcriptional activator proteins D. Cas9 E. ALL of the above proteins directly bind to DNA. 6. Which enzymes are used for converting the molecule on the left to the molecule on the right? I. NDK (NDP kinase) II. RNR (Ribonucleotide reductase) III. Adenylate kinase IV. Thymidylate synthase A. I and II B. II and III C. III and IV D. II and IV E. I and III 7. Which of the following conditions would halt or diminish the synthesis of Ketone bodies? I. When oxaloacetate (OAA) is used for gluconeogenesis in the hepatocytes II. When β-oxidation is decreased in the hepatocytes III. When fat mobilization is increased in the adipocytes A. II only B. I and II only C. II and III only D. I and III only E. I, II, and III

5 8. Which ONE of the following is NOT activated in the small intestine? A. Trypsinogen B. Proelastase C. Pepsinogen D. Chymotrypsinogen E. None of the above 9. Throughout this course we have seen GTP being used in many important biochemical reactions. One day, an angry biochemist tried to disrupt as many biochemical processes as possible by creating a toxin that binds irreversibly to GTP, effectively rendering GTP non- functional in a eukaryotic cell. Using your knowledge from BIOC406, which of the following processes would be directly disrupted by this toxin? I. Targeting of proteins to the secretory pathway II. The chemical reactions in which introns are spliced by the spliceosome III. Selection of correctly base-paired tRNAs by the ribosome IV. Signaling by the glucagon receptor A. IV only B. I, III C. II, IV D. I, III, IV E. II, III, IV 10. You discover a new cheeseburger-shaped organelle, the Kwonoplast! You gaze at the sequence of a number of proteins targeted to the Kwonoplast and find no obvious amino acid sequence that they have in common. You grind up some hot dogs and put them on some cells in a dish to cause random mutations, hoping to identify the targeting sequence in this way. You pick out cells in which proteins are no longer sent to the Kwonoplast but instead are secreted. When you sequence their genome to find out what is wrong, you are surprised to find that none of the Kwonoplast proteins have mutations. Instead, all your mutations are nonsense mutations in a gene encoding a protein palmitoyl transferase that catalyzes the covalent attachment of palmitate to cysteine residues. What is the best explanation of your data? A. Targeting of proteins to the Kwonoplast occurs by a default pathway. B. A sugar modification is required to target proteins to the Kwonoplast. C. A lipid modification is required to target proteins to the Kwonoplast. D. Proteins are targeted to the Kwonoplast via an N-terminal hydrophobic signal sequence. E. Proteins are targeted to the Kwonoplast by disulfide bond formation.

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