Biochem I Problem Set 6a(1) (1)

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Dec 6, 2023

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Biochemistry I – Problem Set #6a Answer the following questions briefly and precisely The following 6 questions refer to the mechanism of the reaction catalyzed by Chymotrypsin, as discussed on pages 204-208 in Lehninger . 1. What reaction does the enzyme catalyze? 2. Assuming an average M.W. of 110 for each amino acid residue, approximately how many residues would you estimate that Chymotrypsin has? _______ 3. Which residue(s) participate(s) directly in general acid-base catalysis? ____________ (Identify the amino acid and its position; e.g., Cys 107 ) 4. Which residue(s) participate(s) directly in covalent catalysis? ______________ 5. Which residue(s) participate(s) assist in the catalytic process by stabilizing transition states? ______________ 6. Chymotrypsin acts on polypeptides at points adjacent to Phe, Trp and Tyr. Based on the structure and function of this enzyme, how do you explain this specificity? The following two questions refer to hexokinase, discussed on pp. 209-210 of Lehninger . 7. What reaction does this enzyme catalyze? 8. Water, a much smaller molecule than the normal substrate of this enzyme, can easily enter and fit into the active site of this enzyme. Why does this enzyme not readily add phosphate to water, and which of the 4 factors contributing to binding energy (Refer to lectures, and pp. 182-186 of Lehninger ) is this an example of? The following two questions refer to enolase, discussed on p. 210 of Lehninger . 9. Of the 3 general types of catalysis (Refer to lectures, and pp. 186-188 of Lehninger ), which is/are involved in the reaction catalyzed by enolase? 10. What cofactor(s) is/are involved in this reaction?
Biochemistry I, P.S. #6 Page 2 The following two questions refer to HIV protease, discussed on pp. 208-209 of Lehninger . 11. What reaction does this enzyme catalyze? 12. Name 4 HIV protease inhibitors. 13. What part of the inhibitors acts as a transition state analog, mimicking an intermediate in the reaction catalyzed by the protease? 14. What part of the inhibitors is structurally similar to the site of action of the protease, and thus helps the inhibitors bind to the active site of the enzyme?
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