Questions PHGY 216 Applied Physiology - PHGY 216 - Online - W24

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Applied Physiology Assighment ‘ G](D Course: Mammalian Physiology Il (PHGY216) Term: Winter 2024 Assignment Title: Applied Physiology Value: 10% Learning Outcomes: CLO2. Understand physiology at the molecular, cellular, and systems levels to explain their combined role in integrative physiology. CLO3. Use physiology to explain pathophysiological states. CLOA4. Apply analytical skills to further knowledge of physiological systems. Competencies: Communicator; Advocate; Leader; Scholar; Professional; Content Expert WHAT ARE YOU DOING? In this assignment, you will be presented with a series of clinical laboratory findings relating to a medical condition relevant to Modules 3-5. You will interpret, explain, and apply these test findings using your knowledge of physiology. WHY ARE YOU DOING IT? This assignment provides you with the opportunity to apply the theoretical knowledge you’ve gained within Modules 3-5 to a practical setting mirroring many of the clinical situations happening across the world at any given moment. This will allow you to translate the concepts learned within the modules to a real-world situation, also fostering knowledge-translation. HOW ARE YOU DOING IT? Using your knowledge of fundamental physiology processes as well as the principles of data visualization (e.g., graphs, tables, and scientific figures), you will: a. Interpret the presented clinical findings — what do they show? b. Explain these findings — how do they relate to fundamental physiology? c. Apply these findings — integrate fundamental information with pathophysiologic (disease- related) knowledge found through research to understand how these test results shed light on the patient’s condition and prognosis. SPECIFICATIONS: Answers requiring a written response much be written in paragraph form with max. 250 words/each. Numeric calculations do not count towards the word count. Any information you include that is not considered “general knowledge” in this course (modules/textbook are general knowledge, but outside sources like journals or website are not general knowledge) must be cited appropriately using APA-style in-text citations and a reference list. 1. Cover Page: Title, Date, Course (code + section), Student ID 2. Written in size 12, Times New Roman, Double-Spaced 3. Please submit 2 copies of your final submission: 1 as PDF, 1 as Word Doc 4. There are 5 questions total. Please number all question responses, with each new response starting on a new page.

ASSIGNMENT QUESTIONS Clinical Scenario LF, a 34 year old white male, presented to the emergency room complaining of acute and severe shortness of breath and intense chest tightness. LF’s speech was choppy and breathing was very rapid and erratic, punctuated by noticeable wheezing. LF’'s medical records included the results of pulmonary function testing he had undergone six months before (Table 1). Table 1. Pre- vs post-bronchodilator spirometry at baseline Pre-Bronchodilator (L) Post-Bronchodilator (L) | Predicted Normal (L) FEV, 3.22 4.25 5.55 FVC 5.20 5.52 6.51 His medical records also indicated prior admission for respiratory symptoms and a history of poorly- controlled asthma. Blood gas tests were performed shortly after LF was admitted (Table 2) and a PEFR (peak expiratory flow rate) test performed. The latter revealed a PEFR of 181 L/min (normal: 525 L/min). LF additionally had serum creatinine measured at admission and at 12h post-admission (Table 3). Table 2. Blood gas values upon admission Admission | +2h +4h +6h +8h +10h +12h Pa02 (mmHg) 65 65 66 66 66 68 70 PaCO; (mmHg) 32 34 35 36 37 38 40 HCOs 27 27 27 25 25 24 24 pH 7.52 7.52 7.51 7.51 7.49 7.48 7.47 SpO; (%) 89 90 90 91 92 93 94 Table 3. Serum creatinine values at admission and after 12h Admission | +12h Sca(mg/dL) 1.55 1.42 LF received high-dose bronchodilator medication through use of a valved holding chamber. This was followed by intravenous glucocorticoids and nebulized bronchodilators every two hours for a twelve-hour period, followed by nebulized bronchodilators every four hours for a forty-eight hour period. After discharge from the hospital, LF was provided a take-home flow meter to monitor his lung function. Table 4 shows LF’s PEFR results during a 30-day period. Table 4. Peak flow monitoring from day 1-30 post-discharge. All PEFR values are given in L/min. PEFR | Day | PEFR | Day | PEFR | Day | PEFR | Day | PEFR | Day | PEFR 495 6 500 11 493 16 503 21 453 26 483 490 7 493 12 483 17 276 22 468 27 500 500 8 510 13 479 18 255 23 492 28 496 478 9 483 14 488 19 277 24 493 29 488 486 10 492 15 491 20 379 25 487 30 489 ulalw|/Nk(§ <

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