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True or False: Chromosomes are in a condensed
form through most of the cell cycle.
false
Match the following each of the following terms
with the correct description
Plasma Membrane.. protects
nuclear membrane.. dissolves
nucleus... contain
er... studded
cytosol.. jelly like
Which of the following is correct
Centrioles are responsible for the formation of spindle fibers.
At which cell cycle phase does the nuclear
membrane break down?
Prophase
The genetic flow of material between organisms is
NOT dependent on which of these criteria?
Independent assortment of the genes
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DNA is condensed within the nucleus (cellular
compartment) by coiling around ____(1)____ proteins.
Modification of these ____(2)____charged proteins
alters them to become either neutral or negatively
charged. Thus, the interaction with ____(3)____charged
DNA is interrupted, and the interactions loosen.
1. histone 2. positively 3. negatively
Interphase marks the period of the cell cycle just
before active cell division. Label the rest of the cell
cycle in order, from 1-5.
1
2
3
4
5
s-phase
prophase
metaphase
anaphase
telophase
Which of the following is true about anaphase?
Chromatids undergo disjunction to travel to opposite poles
A chiasma is a point during meiosis at which the
non-homologous sister chromatids
Intertwine
Which of the following statements is correct?
Incorrect segregation of X and Y chromosomes (for instance, a female with XXX or
X genotype) can produce viable offspring, albeit usually with some problems.
True or false: Linked genes are part of the same
chromosome.
true
Consider genes A, B, and C, which are located on a
chromosome in that order. If genes A and B cross
over 30% of the time, and genes B and C cross over
30% of the time, what is the probability of a double
crossover between A B and C?
(0.3) * (0.3) = 0.09, 9% chance of this crossover
Determination of sex in humans is located on the
_(1)_ chromosome, specifically on the __(2)__ gene.
1. Y
2. SRY
The sex disorder that exhibits an XXY phenotype is
known as ___(1)___. This disorder is found on the __(2)__
sex chromosome
1. Klinefelter syndrome
2. male
Indicate whether each of the following statements
is True or False. 1. G0 is an actively dividing cell
cycle phase. False 2. Cells enter G0 when the
environmental conditions are not ideal for survival.
True 3. Cells in G0 do not undergo active
replication. True 4. When conditions become
normal, cells may go back into the cell cycle. True
false
true
true
true
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Match each of the following terms with the correct
description.
Kinetochore
spindle fibers
centrioloes
metaphase plate
cyclins
flank
made
cytoplasmic
area
blind
kinases
cohesin
histones
shugoshin
phosphorylate
protein complex
hold DNA
protects
A fertilized egg that is the result of fusion of two
gametes is called a ________.
zygote
True or False: The primary male gamete is the
sperm, and the primary female gamete is the
oocyte
true
Which of the following criteria must be met in order
to successfully map genes
Enough offspring should be produced to give a representative sample
True or False: At fertilization, the phenotype of a
male or female is immediately evident.
false
True or False: At fertilization, the phenotype of a
male or female is immediately evident.
G0
The X and Y sex chromosomes are known as _______
chromosomes
Heteromorphic
Why is modification of histone proteins critically
important to DNA transcription?
Modifications of the histone proteins allow for them to either wrap tightly around
DNA or to loosen their grip on DNA. This is very important for transcription
because when histones loosen their grip on DNA, it allows access to the
transcriptional machinery so that DNA can be transcribed. Conversely, when the
histones are tightly wrapped with the DNA, transcription is shut off because the
machinery cannot access the DNA within the space
True or false: The eggs of a female undergo meiosis
I before she is even born, but they undergo meiosis
II after fertilization occurs.
true
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Pointy ears and knobby knees are dominant genes
over round ears and smooth knees. What would be
the result of an F1 cross between one homozygous
parent for pointy ears and knobby knees and one
homozygous for round ears and smooth knees?
What would the F2 cross look like if the F1 was bred
to F1?
If the parents are PPKK x ppkk, then the F1 generation is entirely PpKk and will have
pointy ears and knobby knees. The F2 generation will be as follows: 9:3:3:1- 1 round
ear, smooth knee; 3 round, knobby; 3 pointy, smooth; 9 pointy, knobby
Consider the following 4 independent dominant
traits: short, red, glossy, and tall. Use the product
law to predict the likelihood of inheriting three of
these dominant traits and one recessive trait
3 dominant + 1 recessive = (3/4) (3/4) (3/4) * (1/4) = 27/256
Explain why an individual who is heterozygous for a
genetic disorder may go for a very long time as a
carrier of that disorder without realizing that they
have it?
If an individual is heterozygous for a gene that causes a disorder, the gene that
expresses the normal allele may compensate and produce proteins in enough
quantity that it can function normally. This effect is known as the threshold effect
and essentially can go undetected unless that individual produces offspring that
inherit the recessive gene for the disorder from both individuals. When the
recessive gene from two unaffected individuals are expressed in the offspring,
there is no gene activity produced and the phenotype of the disorder is seen.
The presence of the ABO antigens on the surface
of blood cells is an example of codominance. If a
mother is Type AB (AB) and the father is Type A
(AO), what are the possible combinations for the
child's blood type?
Type A (AA or AO), Type B (BO), Type AB (AB) are all possible.
In the case of determining the likelihood of
inheriting 5 independent alleles, would you use a
Punnett square to make these calculations? If not,
what would you use instead and why?
In determining the likelihood of inheriting 5 independent alleles, you would use the
product law because it will make the calculations much simpler than writing out all
the many possibilities of 5 different traits in an individual.
True or False: A person can only be homozygous or
heterozygous for a given gene.
True
What is the purpose of a testcross, and how is it
done?
A test cross is used to determine whether a plant that is exhibiting a dominant
phenotype is homozygous or heterozygous for that trait. To do a testcross, the
organism with the unknown genotype and dominant phenotype is crossed with a
known homozygous organism.
A homozygous individual will yield all dominant phenotypes whereas a
heterozygous individual will yield a 1:1 mixture of phenotypes.
Let us put the testcross to work. The gene for
yellow flowers is dominant on our favorite plant.
The gene for white flowers is recessive. Our plant
has yellow flowers, but we are unsure of its
genotype. When we crossbreed our unknown with
a plant with white flowers, we get 3 plants with
yellow flowers and 3 plants with white flowers.
What does that tell us about the genotype of the
yellow plant? Draw it out.
If the unknown was YY (homozygous), then YY x yy would yield offspring of Yy, Yy,
Yy, and Yy - all yellow.
If the unknown was Yy (heterozygous), the Yy x yy would yield offspring of Yy, Yy,
yy, and yy - half yellow and half white.
Therefore, our unknown yellow plant must be heterozygous for the yellow gene
(Yy)
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When a mutation does not affect the function or
phenotype of a given gene, it is called a _______
mutation.
Neutral or silent
In a few sentences, summarize Darwin's theory of
natural selection.
Natural selection posited that more offspring were produced than an environment
could actually support. Survival in a crowded environment would lead to struggle
within a population, so the offspring that inherited the most desirable traits for a
certain environment would ultimately survive. Over time, variations would evolve in
offspring that would make them more adaptive, and ultimately over time, new
species could evolve.
Name 2 types of animal models that are used for
genetics research. Describe one trait that each
model possesses that makes it a useful genetic tool.
Mouse- similar genome to human, easy to breed
Fruit fly- extremely cheap, short life, easy to breed, small genome
Worms- inexpensive, simple nervous system, easy to use, short life span
Zebrafish- transparent larvae and embryo
How does preformation differ from epigenesis?
Preformation postulated that a fertilized egg contained a miniaturized version of a
tiny human, called a homunculus. Epigenesis directly contradicted that theory by
stating that a fertilized egg undergoes a series of developmental events that
eventually form a human.
What type of plants did Gregor Mendel use in his
famous experiments?
pea plants
The chromosomal theory of inheritance states that:
Genes, contributed from each parent, are carried on chromosomes.
True or False: Nucleotides are the basic building
blocks that make up DNA.
Correct!
true
Explain how the use of biotechnology has
contributed to modern agriculture.
Transgenic plants have been engineered to resist insects and harsh environments,
grow bigger and more prolifically, or to enhance nutrition.
True or False: The theory of spontaneous
generation posits that living things can
spontaneously generate from nonliving things.
Correct!
true
Natural selection posits that organisms that have
the most advantageous characteristics will survive
their environment. Do humans have the same
selective pressures for natural selection that their
animal counterparts do? Are humans still evolving?
Modern humans have overcome the survival barriers that most animals face. They
(typically) do not face harsh environments or predators because of their ability to
shelter; they do not need to hunt or gather for food because there are markets;
they have equipment and clothing to help them to be strong, to climb, etc. So,
humans do not face the same selective pressures that other animals do for survival.
That being said, they do continue to evolve. Genetic mutations occur within
populations that may be slightly advantageous to a certain lifestyle (eg evolving
the ability to digest milk even into adulthood), and these mutations may be
selected for within a population. So, evolution occurs even though it is no longer a
true "natural selection" for survival.
Cell theory was introduced by:
Matthias Schleiden and Theodor Schwann
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Charles Darwin's publication on evolution is called:
the origin of species
Propose examples of certain traits that could
benefit a mammal that lives in a mountainous
environment.
The ability to climb easily, have good balance, blend in with the colors of
mountains (snow or rocks), to deal with low oxygen levels, and to find food on
rough terrain are traits that would benefit a mountain animal. Answers may vary.
The _________hypothesized that heredity and
development depend on the passing of genetic
information via _______that are contained within
chromosomes.
Chromosomal theory of inheritance; genes
The number of total chromosomes in a normal
human chromosome set is____. Chromosomes exist in
matched numbers of____.
46;2
______ genes are the "normal" genes, such as the red
eye color in the fruit fly. A mutation of a gene is
referred to as an ______.
wild type;allele
How many nucleotides make up DNA? In which
combinations do they pair?
4; A-T and G-C
Corn and soybeans are 90% transgenic crops. What
does this mean?
A transgenic crop has had advantageous traits introduced via recombinant DNA
technology.
The FDA-approved ATryn used to treat blood clots,
was derived from genetically engineered
goats
A ________is carrier DNA in which a gene can be
inserted using specific ________.
vector;restriction enzymes
Which two scientists won the Nobel Prize for their
model of the double-stranded DNA helix?
james watson and francis crick
True or False: Proteins are responsible for carrying
the genetic information within organisms.
false
Which of the following statements is correct?
Dominance and recessiveness are not linked to the sex chromosomes. - Mendels
label of unit factors are what we now refer to as genes.
True or False: A dominant gene will always cause
the expression of a dominant phenotype in any
genetic cross.
false
People with sickle-cell disease can become very
sick under what conditions?
high altitudes
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A homozygous long-haired cat is bred to a
homozygous short-haired cat. Assuming that the
gene for long hair is completely dominant, what are
the chances of the F1 offspring being long-haired?
100%
A dog breeder is looking to cross a long-haired
female dog with a short-haired male dog. The gene
for hair length has incomplete dominance. By
crossing the F1 offspring, what percentage of the F2
generation are predicted to be short-haired?
A 1:2:1 ratio predicts 25% of the offspring to be homozygous short-haired.
Consider 3 genes that assort independently in
squirrels. A gene for brown color is dominant (D), a
gene for a bushy tail is dominant (B), and a gene for
reflux after eating acorns is recessive (a). Use the
product law to predict the likelihood of producing a
squirrel (from parents that are heterozygous for
each trait individually) that is brown, bushy-tailed,
and has reflux from all those acorns.
(3/4) x (3/4) x (1/4) = 9/64 probability of this squirrel being brown, bushy-tailed, and
having reflux.
Two individuals with widow's peaks have a child
with a straight hairline.
A. Is the gene for a widow's peak likely dominant or
recessive?
B. Could you predict the genotype of the parents,
assuming there is no codominance?
C. If the child with the straight hairline someday
marries a person with a widow's peak, can you
predict for certain whether their offspring will have
a widow's peak?
Dominant (WW or Ww) would produce a widow's peak. Because both parents have
widow's peaks, only a homozygous recessive (ww) would result in the opposing
phenotype of a straight hairline.
B. The parents are likely heterozygous for a widow's peak (Ww) to pass along a ww
genotype.
C. You cannot predict for certain, because the other parent could be heterozygous
(Ww) or homozygous (WW) for a widow's peak, and either phenotype (Ww or ww)
could be produced.
Alternate forms of a gene are termed:
alleles
A karyotype is a snapshot of the ______ within the cell.
_______ cells are isolated and stained so that a trained
geneticist can organize them into __________
chromosomes to detect genetic abnormalities.
chromosomes; white blood; homologous or paired
True or False: A normal chromosome set always has
paired X and Y chromosomes.
false
The phenotype for sickle-cell anemia is distortion of
the ______ in afflicted people. This results in depletion
of ______ in the blood and poses a significant risk to
the patients at high_____. Sickle-cell anemia is caused
by ______ mutation(s) in the protein sequence.
red blood cells; oxygen; altitude;one
Why did Mendel choose the pea plant as his
genetics model?
Correct!
it was self fertilizer
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In a cross, the original generation is known as the
______ generation and the first generation of their
offspring is known as the ______ generation.
p1 or parental; f1
Which of Mendel's hypotheses needs a correction?
Make the correction.
Genetic characters are controlled by unit factors
existing in pairs in individual organisms.
When two unlike unit factors responsible for a
single characteristic are present in a single
individual, one unit factor is said to be dominant to
the other, which is said to be recessive.
During the formation of gametes, the paired unit
factors separate, or segregate, randomly so that
each gamete receives one or the other with equal
likelihood.
During gamete formation, segregating pairs of unit
factors assort in pairs.
4. During gamete formation, segregating pairs of unit factors assort independently
to each other.
True or False: A change in genotype does not
always affect a change in phenotype.
true
A mutation in which gene is responsible for a large
number of breast cancers?
BRCA1
The minimum amount of gene product needed to
meet a normal phenotypic expression in an
individual is known as:
the threshold effect
True or False: In codominance, two alleles are fully
expressed regardless of the sex of the organism.
true
The O phenotype in ABO genotyping possesses
how many antigens on the surface of red blood
cells?
0
True or False: Chromosomes are uncondensed and
diffuse for only a short time during the cell cycle.
You Answered
false
Which of the following is correct?
sister chromatids are held together by cohesin
The longest of the stages during mitosis is:
Correct!
prophase
The genetic flow of material between organisms is
NOT dependent on which of these criteria?
independent assortment of the genes
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DNA is condensed within the nucleus (cellular
compartment) by coiling around ____(1)____ proteins.
Modification of these ____(2)____charged proteins
alters them to become either neutral or negatively
charged. Thus, the interaction with ____(3)____charged
DNA is interrupted, and the interactions loosen.
histone;positively;negatively
Which of the following is true about anaphase?
chromatids undergo disjunction to travel to opposite poles
A chiasma is a point during meiosis at which the
non-homologous sister chromatids:
intertwine
Which of the following statements is correct?
The Y chromosome is the driving determinant for sex of an offspring.
Genes that are part of the same chromosome are
said to be ________.
linked
Consider genes A, B, and C, which are located on a
chromosome in that order. If genes A and B cross
over 40% of the time, and genes B and C cross over
30% of the time, what is the probability of a double
crossover between A B and C?
(0.4) * (0.3) = 0.12, 12% chance of this crossover
The _(1)_ chromosome and specifically the ___(2)___
gene on that chromosome, appear to determine
the sex of a human.
y;SRY
Klinefelter syndrome is a disorder of the __(1)__ sex
chromosome and displays a genotype of __(2)__.
male;XXY
Indicate whether each of the following statements
is True or False.
G0 is an actively dividing cell cycle phase. False
Cells enter G0 when the environmental conditions
are not ideal for survival. True
Cells in G0 do not undergo active replication. True
When conditions become normal, cells may go
back into the cell cycle. True
false;true;true;true
A fertilized egg that is the result of fusion of two
gametes is called a ________.
zygote
The primary male gamete is the ___(1)___ and the
primary ___(2)___ gamete is the oocyte.
sperm;female
Which of the following criteria must be met in order
to successfully map genes?
There must be a distinct phenotype for all genes since genotypes cannot be
observed.
True or False: At fertilization, the phenotype of a
male or female is immediately evident.
false
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When cells become quiescent during G0, they are:
Correct!
resting
The X and Y sex chromosomes are known as _______
chromosomes.
heteromorphic
Why is modification of histone proteins critically
important to DNA transcription?
Modifications of the histone proteins allow for them to either wrap tightly around
DNA or to loosen their grip on DNA. This is very important for transcription
because when histones loosen their grip on DNA, it allows access to the
transcriptional machinery so that DNA can be transcribed. Conversely, when the
histones are tightly wrapped with the DNA, transcription is shut off because the
machinery cannot access the DNA within the space.
True or false: The eggs of a female undergo both
meiosis I and meiosis II before she is even born.
false
Explain how have multidrug-resistant pathogens in
agriculture been propagated.
Livestock and animals are provided food treated with continuous low-dose
antibiotics, which are used to enhance the growth of the animals. Over time,
bacteria accrue mutations that lead to resistance to these antibiotics and
eventually pathogenic bacteria are borne with the same resistance, and standard
antibiotic treatment no longer works.
Two auxotrophic bacterial strains are propagated in
the laboratory, one deficient for leucine and the
other deficient for biotin. When cultured alone, they
cannot grow on minimal medium, and when
combined in the same culture media, they still
cannot grow in the minimal media. Can you tell if
genetic transmission occurred in this experiment in
the case of genes that control synthesis of biotin or
leucine?
It does not appear that genetic transmission has occurred in this experiment
involving these genes because even with direct contact, there is no growth rescue
for either of these auxotrophs.
Does spontaneous mutation positively or negatively
affect evolution? Briefly explain your answer.
Spontaneous mutations positively affect evolution because the mutations that
make the organism better able to function or tolerate its environment help it to
survive longer than its wild-type counterparts. The longer-lived organisms are
likely to produce more offspring than those with short survival times. Thus, an
advantageous mutation will be passed on to future generations, and if it truly
enhances survival, it will eventually become the normal (wild-type) gene.
Fill in the blank: A bacterium that can grow well on
minimal medium is an example of a __________.
prototroph
A gene that is expressed all of the time regardless
of conditions is called:
constitutive
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