Week 5

Is cyclopentanamine soluble in water? HCl? NaOH? NaHCO3?

Truo or fals

Selective serotonin reuptake inhibitors (SSRIs) are drugs that can alleviate symptoms of depression by blocking the reuptake of serotonin (5-HT) from the synaptic cleft, thereby increasing the amount of time that 5-HT remains active. Elevated levels of 5-HT within the synapse are associated with feelings of well-being; conversely, low levels of 5-HT are correlated with depressive symptoms. Recent studies have shown that SSRIs can also mediate their antidepressant effects by increasing brain levels of certain cytokines, including interferon gamma (IFNY). IFNY directly induces the expression of the protein p11 in neighboring neurons, which then interacts with 5-HTR4, a 5-HT transmembrane receptor. Figures 1 and 2 provide information about this interaction. 5-HTR4 protein expression (% of WT) CAMP levels (% change control) from MEM TOT Figure 1 5-HTR4 protein expression in plasma membrane-enriched fraction (MEM) of hippocampal lysate and in total hippocampal lysate (TOT) from p11…

Hyperphosphatemia may be found in O Hypoparathyroidism Rickets Hyperparathyroidism O Possible long-term use of aluminum hydroxide gel antacid O AOTA АОТА

2

I need the correct answers very fast please

The KSP for BaCO3 is 5.1X10-9. How many grams of BaCO3 will dissolve in 1000mL of water?

None

The medicine can conditionally be divided into two parts: the active substance and excipients. An active substance is a substance that directly affects the body. Excipients are needed so that the active substance is better absorbed by the body (for example, so that the tablet dissolves only in the stomach, and not earlier). The active substance for a number ofdrugs are:a) KCl - replenishing potassium deficiency,b) KBr - sedative,c) KI - replenishing iodine deficiency, d) CH3COOK - diuretic,e) KMnO4 - disinfectant. Determine the mass fraction of potassium in the above drugs (the mass fraction of excipients for all a)-d) preparations should be equal to 95%, for KMnO4 there are no auxiliary substances). Determine the pH of 0.1 M solution of salts mentioned in a) - e) (appropriate constants find in literature).

Please show how you would rank drug A and drug B using these 5 keywords Solubility• (please include Turbidimetric measurement) Permeability• (Please include Caco-2) Metabolism• ( please include Microsomal stability•) Drug-Drug Interactions (Please include CYP450 inhibition and induction•) Novelty (Please include •Clear patentability)

Please modify this drug (tamoxifen) to make it water soluble and easy to be absorbed in stomach? H₂C-N CH3 CH3

Aspirin reduces the inflammation and fever through which of the following possible mechanism of action? Delay the secretion of the local hormone Leukotriene Preventing the promotion of thromboxanes in blood vessels Inhibit enzymes leading to prostaglandin synthesis Promotion of various inflammatory and hypersensitivity reactions

Choose among these options Among these Inhibits the enzyme which is responsible for the assembly of matured viral particles   Saquinavir Didanosine Penciclovir Azidothymidine The following are essential components in the structure of sulfonamides with the exception of Amino group   Benzene ring   Pyridine N-Acyl amino This drug has been associated with optic neuritis and therefore discontinued after 2 months of treatment Isonizaid Rifampicin Ethambutol Pyrazinamide A non prodrug ACE Inhibitor Captopril Enalapril Quinapril Fosinopril High sodium diet High fat diet Low potassium diet Low phosphate diet

Explain the function of an emulsifier. Relate your explanation to your observation in the emulsification test. Samples used: Test tube 1: 1 mL coconut oil + 5 drops 0.1% bile salt solution Test tube 2: 1 mL coconut oil + 5 drops H2O + tiny crystal of cholesterol Test tube 3: 1 mL olive oil + 5 drops 1% aqueous solution of lecithin

a) Lysine is an essential amino acid. It is taken by some people as a nutritional supplement in the form of a hydrated crystalline solid with the formula C6H₁4N2O2.XH₂O . To control the dose of lysine, it is essential to know the complete formula of the hydrate, which means determining the value of x. To determine the value of x in lysine hydrate, a pharmacist used a direct titration method. She dissolved 6.258g of the compound in approximately 100mL of distilled water and then made this up to 250mL in a volumetric flask. She then titrated 25mL aliquots of this solution with a standardized NaOH solution of concentration 0.1050 mol dm-³, obtaining a mean titre of 36.30 mL. In titrations, lysine behaves as a monoprotic acid. Use these data to determine the value of x in lysine hydrate. b) In a second experiment to verify the value of x, the pharmacist heated a 3.752g sample of the lysine hydrate to drive off all the water. When she reweighed the sample, the mass was 3.278 g. Use this…

Among the following approved sweeteners, which has the highest relative sweetness?​     a)  ​aspartame   b)  neotame   c)  ​acesulfame-K   d)  ​tagatose

Hello, these questions were not answered and I was wondering if I could get  some help answering them .

As seen at the end of Section 16.10, a deficiency in vitamin D can cause a bonesoftening disease called rickets, so many foods, including milk and cereals, are fortified with vitamin D. Our bodies synthesize vitamin D when our skin is exposed to sunlight, but the lack of outdoor exercise by today's children, in conjunction with regular use of sunscreen, may be contributing to a rise in the disease. The amount of vitamin D3 in fortified foods and fish can be measured by UV-Vis spectrometry. (J. Agric. Food Chem. 2009, 57, 2135-2146.) Using Woodward-Fieser rules, estimate the expected Amax for vitamin D3: HO.. Vitamin D3 CH3 nm H CH3 Select the number of each feature present in vitamin D3. Base value (conjugated diene) = 217 nm Number of additional double bonds: Number of auxochromic alkyl groups: Number of exocyclic double bonds: Number of homoannular dienes: Estimated Amax= ✓ (+30 each) ✓ (+5 each) ✓ (+5 each) (+39 each)

1. A daily low dosage of aspirin (acetylsalicylic acid) can lower the risk of heart attack and stroke for individuals at risk. Aspirin suppresses the generation of prostaglandins by irreversible binding to the enzyme COX-1. Inhibition of prostaglandin synthesis lowers the production of thromboxanes that are responsible for the aggregation of platelets and the formation of blood clots. You will explore the mechanism of aspirin binding. 1.1 The average pH of the human body is 7.4 (also known as a physiological pH). Draw the structure of aspirin at a physiological pH. OH 1.2 Aspirin reacts with the amino acid Serine. What is the structure of serine? Draw the structure of the tripeptide Ala-Ser-Trp (draw these structures as they exist at physiological pH) serine Ala-Ser-Trp 1.3 Aspirin reacts with Serine 530 of COX-1 by transesterification reaction. Draw a general mechanism of acid-catalyzed transesterification reaction. Use HA as an acid. 1.4 Draw an arrow-pushing mechanism for the…

Complete the following chemical reactions according to the type it belongs to:

Of the choices, could you please advise which would be best?

(a) Write the deprotonation equations for citric acid FÓRMULA pKal pK2 pK23 pKa4 он HO-C–CH2–C–CH2–Ĉ–OH 2.94 4.14 5.82 16.0 0=C–OH

This pre-analytical variable can have an effect on chemistry tests which are read visually by spectrophotometry:   Question 8 options:   all answers are correct   icterus   lipemia   hemolysis