Analysis of Asa in Aspirin Tablets

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EXPERIMENT 2- ANALYSIS OF ASPIRIN
MATTHEW SKILTON

DUE MONDAY FEBRUARY 13TH 2012
TA- ANA GARGAUN

ABSTRACT

In this experiment the concentration of acetyl salicylic acid (ASA) in an aspirin tablet will be determined. This can be done by dissolving a tablet in a strong base, NaOH, and titration it with a strong acid, HCl. The quantity was found to be about 75.5% of the weight of the tablet, or about 318 mg per tablet. This value tells the pharmaceutical companies how much to state the recommended dosage as based on how much ASA is needed to feel the headache and pain resistant effects. Also it can be used to state precautions for the customers based on the known LD50 value (200 mg/kg).

INTRODUCTION

1) This experiment is used to find out
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Calculated Values for Concentration of ASA in tablets (with group values, excluding major outliers) Flask Number | Trial Number | Percent Weight (%) | Uncertainty of Percent Weight (±%) | Mean Percent Weight (%) | Mean Group Percent Weight (%) | Mass in tablet (mg/tablet) | Uncertainty of Mass in tablet (±mg/tablet) | Mean Mass in tablet (mg/tablet) | Mean Group Mass in tablet (mg/tablet) | 1 | 1 | 76.34 | 5.345 | 74.65 ±5.410 | 78.13 | 323.8 | 88.83 | 316.7±88.83 | 327.1 | | 2 | 72.96 | 5.410 | | | 309.5 | 85.23 | | | 2 | 1 | 72.70 | 5.577 | 76.98±5.577 | | 301.8 | 85.00 | 319.6±92.75 | | | 2 | 78.28 | 5.471 | | | 324.9 | 90.95 | | | | 3 | 79.96 | 5.442 | | | 331.9 | 92.75 | | | 3 | 1 | 73.66 | 5.396 | 75.00±5.396 | | 312.4 | 85.97 | 318.1±88.83 | | | 2 | 76.34 | 5.345 | | | 323.8 | 88.83 | | |

TABLE 5- Calculated Values for Concentration of ASA in Powder (with group values excluding major outliers) Flask Number | Trial Number | Percent Weight (%) | Uncertainty of Percent Weight (±%) | Mean Percent Weight (%) | Mean Group Percent Weight (%) | 1 | 1 | 74.15 | 5.462 | 75.98±5.462 | 78.55 | | 2 | 77.82 | 5.394 | | |

TABLE 6- Results for t-test Flask Number | Result for Percent Weight | Result for Group Percent Weight | Result for Concentration | Result for Group Concentration | 1 | 3.166 | 2.062 | 1.162 | 0.5093 | 2 | 1.376 | | 0.5984 | | 3 | 3.725 | | 1.204 | | Powder 1 | 2.185 | 1.233 | --- | --- |

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