Essay On Scaffolds

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Currently, there is a global increase in cases of bone disorders and conditions, which is expected to increase as twice as much by 2020 particularly in countries where obesity and poor physical activity are associated with aging[1]. Although reconstructive orthopaedic surgery can be used to treat bone defects and injuries caused by trauma, additional treatments are required for severe breaks or pathological conditions as well as critical bone defects due to malformation, cancer or osteoporosis in order to effectively stimulate healing and regeneration. While traditional autologous and allogeneic bone grafting is ineffective for treating large injuries because of lack of graft vascularization, low cell viability in the host, and other…show more content…
Poly (ε-caprolactone) is an aliphatic polyester that is commonly used for biomedical applications as well as for tissue engineering and drug delivery. The physical and biological properties of PCL makes it a useful biomedical material[7]. Because PCL contains five CH2 Moieties in its repeating units, it doesn't degrade quickly which makes it suitable for commercial sutures or delivery devices as well as for applications requiring a long term load[8]. In addition, due to the fact that the aliphatic ester linkage of PCL is susceptible to hydrolysis, it is likely to undergo hydrolytic degradation [4, 5, 9]. Poly(lactic-co-glycolic acid) (PLGA) is a good material for preparing scaffolds because its material properties can be modified to be more extensive by adjusting the molecular range as well as the lactic acid (LA)/glycolic acid (GA) ratios, unlike the poor characteristics exhibited by pure polylactic acid and polyglycolic acid. PLGA has been extensively used in bone tissue engineering in various ways (7-10). It is widely believed that the mechanical properties of bone tissue can be supported by PLGA scaffolds which take about 4 to 8 weeks to construct [10-12]. The orange/yellow pigment that is responsible
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