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Metabolic Syndrome Essay

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Liver is known as the metabolic port of entry for any endobiotic and xenobiotic substance. The anabolism and catabolism of most of the nutrients are in major performed by the liver. Carbohydrate, protein and fat metabolism by the liver is of significance as the anomalies in metabolism of these nutrients may introduce several types of metabolic syndromes. The protective effects of aqueous green tea extract have been shown on hyperglycaemia, hyperlipidaemia and liver dysfunction in diabetic and obese rat models [74]. Different nutrients combinations were tested in a long-term feeding in experimental mouse model. Regional and continental food habit and practices are very much different. Effects of Western, vegetarian, and Japanese dietary fat…show more content…
Compared to diabetic control rats, total antioxidant levels were significantly increased in GTE supplemented rats. Inversely, malondialdehyde levels and AT(1) receptor were significantly lower in the GTE supplemented diabetic group [77]. Catechin and its derivatives in green tea are shown to be therapeutically very effective.
Catechin has been shown to modulate the hepatic microsomal phospholipase A2 activities. It can change the hepatic phospholipid species in streptozotocin-induced diabetic rats [78]. On the other hand epigallocatechin gallate, a constituent of green tea, represses the hepatic glucose production. EGCG also mimics insulin by increasing phosphoinositide 3-kinase, mitogen-activated protein kinase. Furthermore, EGCG has been shown to regulate genes that encode gluconeogenic enzymes and protein-tyrosine phosphorylation by modulating the redox state of the cell. These finding suggest that EGCG, or derivatives can perform as antidiabetic agent [79]. Green tea has also been shown in vivo to down regulate the hepatic gluconeogenic gene-expressions of enzymes. The results of this study support the idea that green tea intake may be favorable in the prevention of diabetes mellitus [80]. Diabetes is multi-causal disease. Even the onset of the disease is caused by a single factor but its progression and pathogenesis may be attributed by a number of confounding factors. So, in some
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