Metabolic Syndrome Essay

Metabolic Syndrome Metabolic syndrome has an enormous impact the United States economically. Heart disease, diabetes, and obesity are all the result of metabolic syndrome and each requires a tremendous amount of health care. Hormone imbalances can be part of the cause which require medication and hormone supplements which are costly. Unhealthy bodies break down faster and which means they require treatment longer.

This indicates that the metabolism of proteins was apparently affected by Ch.t extract. The improvement on the levels of protein and albumin in the diabetic treated groups show that Ch.t extract have significant effect in glucose and protein level because insulin inhibit gluconeogenesis from protein [ ] or could be due to improvement in renal function. This affirmative agrees with the fact that the weight of skeletal muscles was significantly increase in diabetic rats treated with Ch.t extract. The decrease in albumin level documented for diabetic rats may be due to liver massive necrosis, deterioration of liver function, hepatic resistance to insulin and glycogen impairment of oxidative phosphorylation[ ].Under the same experimental conditions serum globulin level revealed an appreciable decrease[ ]. The renal pathogenesis is related to duration of diabetes, the most devastating complication with diabetes is nephropathy[

Metabolic syndrome is an emerging diagnosis in the medical field that has effects on patient care. Becoming familiar with it and having it become a common part of patient care will, if used appropriately will increase the lives of those who have become affected with or are at risk of becoming diagnosed with metabolic syndrome. Metabolic syndrome is a constellation of risks factors of metabolic origin that are accompanied by the increased risk of cardiovascular disease and type 2 diabetes. There are five major factors to look for; out of these five a person only needs three to be diagnosis with metabolic

1-Steps of the scientific method in the research on mice and the effectiveness of coffee against high blood sugar:

This is because cinnamon has antioxidant properties and seem to increase one’s sensitivity to insulin. Biologically, these chemicals help your mitochondria to function properly. Likewise, they help regulate blood glucose and lipid levels. These are important because the mitochondria also helps provide energy and keep nerves functioning and alive. Lastly, they help reduce the likelihood of contracting type 2 diabetes.

Several studies described that a significant increase in lipid peroxidation were noted in diabetic rats (Limaye et al., 2003). The present findings are in accordance also with previous report indicated significant increase in TBARS in STZ diabetic rats (Murugan and Pari, 2006). The lipid peroxidation may attribute to the hypoinsulinemia caused by STZ progressive deterioration of normal pancreatic β-cell function. This hypoinsulinemia induced an increase in the activity of fatty acyl Co-A oxidase that initiate the β-oxidation of fatty acids resulting in lipid peroxidation (Baynes and

Students found that rats that were fed with a higher fat diet had higher blood glucose levels than the rats that consumed the lean diet. With the introduction of insulin, the blood glucose levels decreased for both diets after the initial injection. Both rats showed a stabilization after the initial decrease. When the rats were exposed to glucagon there was an increase in blood glucose levels initially and then there was a stabilization for both rats on the various diets. Kadota and colleagues researched the correlation of cardiovascular mortality and blood glucose levels. They found that glucose tolerance plays an important role in cardiovascular motility. The risk becomes higher when associated with obesity. When glucose tolerance is weakened along with an increase of fat in the diet there is a significant chance that people will develop cardiovascular disease (Kadota et al., 2007).

Turmeric has been observed to be a standout amongst the most intense nourishments for keeping up a healthy liver, since it ensures the liver against toxic harm, and even recovers damaged liver cells. Turmeric likewise supports the regular production of bile; a therapist engorged hepatic conduits, and enhances general capacity of the gallbladder, another body-purging organ.

High blood glucose levels and enhanced oxidative stress, found in both clinical and experimental diabetes, are thought to be the main cause of chronic diabetic complications.

This model is better than genetic models because it simulates the natural pathogenesis with producing many metabolic characteristics that are similar to the human pathogenesis of T2DM (Chen and Wang, 2005). Diabetic rats were treated propolis, 2-hudroxy chalcone, and their combination. After 4 weeks of HFD intake, weight gain was observed in the HFD-fed group, compared to control group. This additional weight gain on HFD feeding has been shown in several studies (Srinivasan et al., 2005; Zhang et al., 2008; Singh et al., 2014). The body weight reduce in diabetic rats could be explained by many reasons, including dehydration as well as excessive fats and proteins catabolism (Hakim ZS et al 1997), which ultimately leads to muscle wasting (Rajkumar L et al1991). In addition, the consumption of energy dense diet high in saturated fat, its deposition in various body fat pads, and decreased energy expenditure (Singh et al., 2014). Many researchers that have used the HFD-STZ model also showed the significant loss in body weight after STZ injection. On the contrary, rats treated with propolis showed non-significant increase in body weight compared to diabetic group, on the other hand 2-hydroxy chalcone and combination treated rats non-significant changes in body weight compared to control group, which could be attributed to better control of hyperglycemic state of propolis

and 8 weeks of streptozotocin (STZ)-induced diabetes in rats and the effect(s) of ginger (500 mg/kg/day).

Although, classical oral antihyperglycaemic agents are the mainstay treatment of type 2 diabetes, they fail to prevent diabetic complications (Bergenstal, Bailey, & Kendall, 2010). This, therefore, justifies the search for more efficacious drugs. Although modern medicine has provided drugs belonging to classes including thiazolidinediones, GLP-1 mimetics and DPP-IV inhibitors (Krentz, Patel, & Bailey, 2008), there is still a need for new agents with better potential and physiological antidiabetic actions for the treatment of diabetes. Therapeutic potential of phytochemicals in the management of many human diseases, including diabetes, have been widely acknowledged. However, scientific studies assessing the potentially

Toll-like receptor 4 (TLR-4) plays important roles in innate immunity. Changes in the reduction-oxidation balance of tissues can lead to a pro-inflammatory state and insulin resistance. An action thought to be mediated by TLRs. Omega-3 fatty acids and Peroxisome Proliferator Activated Receptor gamma (PPAR-γ) agonists as pioglitazone are used for decreasing inflammation. The aim of this study is to investigate the anti-diabetic effects of combining omega -3 fatty acid with pioglitazone on type 2 diabetes, and the modulating effects on TLR-4. Type 2 diabetes was induced in male Sprague-Dawley rats by combination of high fat diet and low dose streptozotocin (35 mg/kg). Diabetic rats were treated with omega-3 fatty acids (10% W/W diet), pioglitazone (20 mg/kg), and their combination for 4 weeks. Omega-3 fatty acids and the combination treatment significantly decreased TLR-4 activation. Omega-3 fatty acids, pioglitazone, and their combination significantly decreased TLR-4 mRNA expression, hepatic malondialdehyde, total cholesterol and triglycerides levels, compared to diabetic group. Pioglitazone and the

Objective: There are some studies about the good effects of herbal drugs on blood glucose . This clinical trial was designed to evaluate the synergism effect of Peganum harmala,Quercus infectoria,Vaccinium myrtillus, Citrullos colocynthis, Securigera securidaca with different nature on blood glucose .

A recent and exciting new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera plant, which is very commonly known as Ashwagandha or Indian ginseng or Indian winter cherry, can exert profound therapeutic beneficial effect on metabolic syndrome (increased body weight, hepatic steatosis, insulin resistance and hypertension) in mice.