Nanoparticles As Targeted Therapies : A New Generation Of Cancer Treatments

1473 Words Nov 4th, 2015 6 Pages
Name: Kevin Lam
Student number: 688524
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Nanoparticles as Targeted Therapies: A New Generation of Cancer Treatments

1 abstract only in 2nd page

1. Introduction
2. Definition of Nanotherapy Nanotherapy is a novel therapy that depends on nanotechnology, nanomaterial and nanoparticles to improve certain drug properties (e.g. solubility, stability, half-lives, transportation, etc.) used to treat diseases (Harris et al. 2006). Moreover, the size of submicron sized molecular devices and nanoparticles are limited from 5-500nm in at least one dimension. The size of the drug is between 10-100nm in diameter, however, 20 fold in co-delivery over free CDDP drug indicated that the nanoparticle provide a longer circulating half-life and stay stable in the systemic circulation, therefore confer a higher and more prolonged efficacy. More importantly, compared with free drug delivery, TM(CDDP/PTX) co-delivery was found that PTX accumulation in the kidney was significantly reduced due to the lower dosage of PTX used. Also, the lower level of plasma blood urea nitrogen (BUN), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were observed which imply reduced PTX-associated nephrotoxicity and renal effects. However, concentration of PTX in liver and spleen in mice had 2-5 fold higher than the free CDDP delivery due to sustained blood circulation. Toxicity was therefore increased in those 2 organs.
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