1. What advantages do anonymous DNA markers afford for genetic mapping as opposed to traditional allelic markers associated with visible phenotypes? What are the disadvantages of anonymous DNA markers for mapping? 2. Would you be more likely to find SNPs in the protein-coding or in the noncoding DNA of the human genome
Q: 1. What are some of the medical applications of karyotyping? 2 What kind of chromosomal aberration…
A: Genetic abnormalities are conditions caused by changes to the genes or chromosomes. Inherited…
Q: 1. Identical twins may show dissimilar phenotypes due to changed methylation patterns of the…
A: * monozygotic twins even they are genetically identical there will be some variation in them the…
Q: 2. Imagine a combination of microevolutionary mechanisms other than mutation/se- lection. How do you…
A: Microevolution is characterized as the adjustment of the allele frequencies over the long haul in a…
Q: Dihybrid In rabbits, grey hair is dominant to white hair. Also in rabbits, black eyes are dominant…
A: Sir Gregor Johann Mendel framed Mendel's Laws of Inheritance in order to simplify genetic studies.…
Q: 6. A testcross is used to investigate two linked loci. There are four phenotypes among the progeny.…
A: Unlinked genes. -Genes located on a different chromosome or far apart on the same chromosome.…
Q: Traditional gene mapping has been applied successfully to a variety of organisms including yeast,…
A: Genetic mapping is a method to identify exactly which chromosome has which gene and exactly showing…
Q: 6. Identify the mode of inheritance for the following pedigree. Provide the genotypes of indicated…
A: In human genetics, the pedigree analysis is crucial when we analyze the inheritance pattern of genes…
Q: QUESTIVIES You are studying a group of individuals with X-ray vision and perform linkage analysis…
A: Restrictions enzyme or endonuclease are the enzyme which can cut the DNA at specific sites. Two…
Q: 1) What is the human gene TRNT1? Explain what the wild type and mutant forms do.
A: TRNT1 is a CCA adding transfer RNA nucleotidyl transferase enzyme. The deficiency of this enzyme…
Q: We now know a great deal about the genetics of humans, and humans are the focus of many genetic…
A: Genetics is the branch of Biology dealing with the study of genes including their structure,…
Q: 2, Two unlinked loci effect mouse hair color. CC or Cc mice are agouti. Mice with genotype cc are…
A: Epistasis is the phenomenon in which the effect of one gene is dependent on the presence or absence…
Q: 1. The Human Genome Project has demonstrated that in humans of all races and nationalities…
A: The Human Genome Project was an international, collaborative research project whose aim was to map…
Q: You are making a genetic map and use a cross to measure the distance between genes H and J as…
A: A physical genetic map shows relative distance between genes on a chromosome.
Q: . Why is the relationship P=p2 used for homozygous loci?
A: Introduction :- Homozygous for a given locus refers to diploid and polyploid cells that have the…
Q: 3) Below are two homologous chromosomes. The top chromosome has suffered a double-strand break.…
A: When a DNA strand suffers a damage as shown above, it repairs by homologous recombination. The step…
Q: 1) If you wanted to create a clone of yourself, what would you donate_to start to the cloning…
A: Almost all cells in the body contain the genetic blueprint for the whole organism. Few cells lack…
Q: 4. Draw a diagram clearly showing how intragenic recombination can take an individual who is cc and…
A:
Q: 6. What is a major difference between genetic maps based on recombination frequency and physical…
A: Genetic map Genetic map is made from the recombinant frequency of genetic marker. Genetic map tells…
Q: Where can you find linked genes
A: Genes that are found close together on the same chromosome are called linked genes.
Q: 2. In humans, widow's peak (W) is dominant over a continuous hairline (w), and short fingers (F) are…
A: The dominant trait conceals the effect of recessive trait. The recessive trait can be expressed only…
Q: 4. The bars in the following sequence indicate the break 5'-CGGGTAТСТАСТААА| TTCGCACTТАCGAGGAТТААСАТ…
A: Introduction : Primers are small, chemically synthesised oligonucleotides that are complementary to…
Q: If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one…
A: Hemophilia is a genetic disorder that causes internal and external bleeding by preventing blood from…
Q: 6. What is the most likely order of the linked genes R, S, and T if the distance between R and S is…
A: Linked genes are the genes that are present very closely to one another on a chromosome. Due to this…
Q: 5. What is the difference between an allele and a locus? 6. Why do forensic labs analyze non-coding…
A: The DNA sample from the crime scene can be amplified, or copied in large numbers using a technique…
Q: 3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the…
A: Genes are the functional unit of heredity. Genes are made up of DNA and they carry coded genetic…
Q: 1. a. Examine the following image showing the results of an ALU insert gel-like. The first lane is…
A: Introduction :- Alu insertions, which are unique to primates, are 300-bp bipartite interspersed…
Q: The majority of direct-to-consumer genetic tests: A) must be obtained through a doctor B) makes…
A: Genetic tests are a type of medical test that looks for changes in genes, chromosomes, or proteins.…
Q: 1. (a) You are a genetic counsellor at Penang General Hospital. A couple comes to you worried about…
A: Sickle cell anemia is a genetic disorder in which the shape of red blood cell changes into crescent…
Q: Many genetic counselors will not provide presymptomatic genetic testing for Huntington disease to…
A: The genes are the hereditary unit of the organism that is passed on by the parents to the offspring.…
Q: 2) We hear of a mother with 10 natural children, 8 of whom have blue eyes while the other two (one…
A: Genetics is a field of study that deals with heredity and genetic factors. Eye color is a genetic…
Q: 6. Section 2.6 describes several lines of support for the concept that "that variation in DNA on its…
A: A polymorphism is the multiple alternative forms within a protein or nucleic acid sequence. The…
Q: 5. Hemophilia is caused by an X-linked recessive mutation in humans. If a woman whose paternal uncle…
A: In the disease called “haemophilia”, if a wound is created, the blood does not clot normally. This…
Q: If Ethidium bromide was not added to a gel, what would happen?
A: According to guidelines we have to answer the first question only. so please kindly post the…
Q: 3. Carol has a sister who has not been tested for the APP mutation. What is the likelihood…
A: Alzheimer's disease is a autosomal dominant disease that means at least 1 allele of mutated gene…
Q: DNA sequencing of your own two β-globin genes (one from each of your two Chromosome 11s) reveals a…
A: I should be worried since presence of an abnormal beta globin chains may be an early indicator of…
Q: 3. To determine the recombination frequency between body color and wing genes in flies, you perform…
A: Introduction: Consider a hypothetical condition where a fly has two characteristics, such as the…
Q: Discuss the basic structure and function of DNA as the genetic material.
A: Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions for the…
Q: . what is The theory that genetic information is transmitted from one generation to the next as…
A: The hereditary is important thing which is transferred from one generation to next generation.
Q: 1. Why is statistics important in genetic studies? 2. What importance of sample size in studies…
A: In biology, diversity plays an important role. The diversity is due to the variations in the genes…
Q: 6. List two factors that can create incomplete or low quality data in genomics, and 2) their…
A: *Data integration is relevant in genomics because health related decisions depend on it. * After…
Q: 7. You've completed several two gene mapping experiments and found the followingt results in cM. a-b…
A: Gene mapping Gene mapping is the method to describe the locus and distance between genes.
Q: 9.) In humans, when a dark-skinned person reproduces with a very light-skinned person, their…
A: When a cross is made between two sets of genes that results in different observed traits, this is…
Q: A research team interested in mapping human genes discovered a new restriction length polymorphism…
A: Restriction fragment length polymorphism (RFLP) is a form of polymorphism that occurs when…
Q: 1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s…
A: Genetic tests for Huntington's disease can be performed at any age of an individual, even at the…
Q: vg* qu* 230 vg qu 224 vg qu+ 97 vg* qu 99 Test the hypothesis that the genes quiver and vestigial…
A: The determination chi-square value is a statistical method used to relate data expected with data…
Q: The following diagram shows the genetic map of an individual in the region of a gene that has a…
A: There are fifty percent chances of child getting marfan syndrome because marfan syndrome is caused…
Q: 6. There are two enzymes LDH1 and LDH2. The gene that encodes this enzyme is X-linked. You extract…
A: Humans carry 23 pairs of chromosomes - 22 pairs of autosomes and 1 pair of sex chromosomes. Males…
Q: 4. How can the different gene interactions be differentiated from each other and from the Mendelian…
A: Answer:- Mendelian inheritance refers to the expression of monogenic traits, i.e. gene expression is…
Q: In a DNA study, from a patient with mental retardation, the FMR1 gene is located, which causes many…
A: Mutations are sudden heritable changes in the nucleotide sequence that alters the amino acid and…
1. What advantages do anonymous DNA markers afford for genetic mapping as opposed to traditional allelic markers associated with visible
2. Would you be more likely to find SNPs in the protein-coding or in the noncoding DNA of the human genome?
Step by step
Solved in 2 steps
- 1. a) If you were at risk of a fatal disease such as Huntington’s disease and only the 95% accurate preliminary genetic test was available, would you take the test? After all, 95% of the time the test would tell you whether you would eventually get Huntington’s disease or whether you did not have to worry about getting this disease. b) The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. In a large sample of the Venezuelan family, what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?4) The government of Iceland has built a database which contains genetic informaiton about individuals using SNP analysis and other methods, which can be used to help diagnose pre-disposition to genetic diseases and other conditions. What are some ethical issues that are raised by compiling such a database?1. Why would multi-gene families complicate things in terms of being sure of which member of the family was responsible for a particular phenotype? 2. How could multi-genes families complicate things in terms of using CRISPR to knock out a target gene and achieve a target phenotype?
- Why is it more efficient to perform a test cross with a homozygous recessive donor than a homozygous dominant donor? How could the same information still he found with a homozygous dominant donor?1. What do we need to consider in choosing the best method in introducing recombinant DNA? Compare and contrast at least three considerations (in terms of methods or requirements) in introducing recombinant DNA in plant calli vs animal cell lines. Answer this comprehensively and clearly.1. There are two different variations at STR locus THO1. Where did these variations come from? b) The STR locus D21S11 only has one variation. Why?
- 1. What are the possible effect or consequences if the sequence homology is ignored in homologous recombination? List all possible consequence and explain it comprehensively.1. What are the considerations we need to consider in introducing recombinant DNA in plant calli and in animal cell lines? (Give at least three considerations) Explain and answer this comprehensively.1. What are the considerations we need to consider in choosing methods in introducing recombinant DNA in plant calli vs in animal cell lines? (Give at least three considerations) Explain and answer this comprehensively.
- 6) If you had the ability to do gene editing with ONE gene for the betterment of human kind, which one would you choose, and why? Assume you could either change an abnormal allele associated with a disease, such as the cystin gene associated with Cystic Fibrosis to its normal wild type, or add a pre-existing human allele to a genome1.) What characteristics of VNTR and STR make them useful for DNA fingerprinting? 2.) How does PCR minimize the problems associated with degraded DNA? 3.) What factors can cause DNA to become degraded? 4.) If Ethidium bromide was not added to a gel, what would happen? 5.) How can you tell if an individual is heterozygous for the D1S80 marker? 6.) If a negative control produces a band, what does this indicate? 7.) In an experiment, a student’s sample amplified for D1S80 produced 3 bands. It was the only DNA sample run on the gel. The student knows that there was no problem with the Thermocycler or primers because the other students in the class had the expected results of only one or two bands. What is the most likely explanation for these results?1. You are studying a new gene “X” that you think controls skin color in Bearded Dragons. In order to determine what gene X does, you need lots of gene X DNA to work with. So, you decide to amplify it through the process known as PCR. You have a forward and a reverse primer that have been designed to gene Xf – a gene in frogs that is similar to the one found in the Bearded Dragon. You are pretty sure that these two primers will work in Bearded Dragons, so you decide to go ahead with the PCR. In frogs, the Forward Xf primer binds gene Xf between nucleotides 32 and 47. The Reverse Xf primer binds between nucleotides 1110 and 1135. a. What size PCR product would these two primers create if they amplified the frog gene Xf?? 3. A fellow lab worker brings you DNA containing what might be a similar gene in Leopard Geckos (XG). She asks you to see if you can amplify it using the same primers you used in frogs and the Bearded Dragon. You run the PCR and then analyze the product by…