A 31 year old woman consults her physicain because she is concerned about developing breast cancer. She is currently in good health and she has never had any breast disease. Her concern arises bacause her sister has just been diagnosed as having breast cancer and her mother died of breast cancer. a. How can one determ ine if the cancer in this family is likely to be a dominantly inherited predisposition? b. What is the wom an's cahnce of developing breast cancer?

A 31 year old woman consults her physicain because she is concerned about developing breast cancer. She is currently in good health and she has never had any breast disease. Her concern arises bacause her sister has just been diagnosed as having breast cancer and her mother died of breast cancer. a. How can one determ ine if the cancer in this family is likely to be a dominantly inherited predisposition? b. What is the wom an's cahnce of developing breast cancer?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter16: Reproductive Technology, Genetic Testing, And Gene Therapy

Section: Chapter Questions

Problem 9QP: Cystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites...

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Huntington disease is a rare dominant condition in humans that results in a slow but inexorable deteriorationof the nervous system. The disease shows what mightbe called age-dependent penetrance, which is to saythat the probability that a person with the Huntingtongenotype will express the phenotype varies with age.Assume that 50% of those inheriting the HD allele willexpress the symptoms by age 40. Susan is a 35-yearold woman whose father has Huntington disease. Shecurrently shows no symptoms. What is the probabilitythat Susan will show symptoms in five years?
Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?
Identical twins are produced from the same sperm and egg (whichsplits after the first mitotic division), whereas fraternal twins areproduced from separate sperm and separate egg cells. If two parentswith brown eyes (a dominant trait) produce one twin boy with blueeyes, what are the following probabilities?A. If the other twin is identical, he will have blue eyes.B. If the other twin is fraternal, he or she will have blue eyes.C. If the other twin is fraternal, he or she will transmit the blueeye allele to his or her offspring.D. The parents are both heterozygotes.
Unattached earlobes (E) are dominant over attached earlobes (e) [Figure (a) and (b)]. If a woman with unattached earlobes and a man with attached earlobes have children, what percentage of their children has the possibility of having unattached earlobes if the mother is homozygous for the trait?
In humans, unattached earlobes (E) are dominant to attached earlobes (e). If a child is born with unattached earlobes, and a mother with attached earlobes, and a dad with unattached earlobes, what is genotype of the dad? O a. EE or Ee O b. ee O c. Ee O d. Ee or ee O e. EE
In individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor recessive gene. If 2 normal parents had a daughter with the symptoms ofthis disease, and a normal son, what is the probability that he might be acarrier of the recessive gene?Express answer in fraction form.
A blue eyed man (A) both of whose parents (B&C) were brown eyed, marries a brown eyed woman (D) whose father (E) was blue eyed and whose mother (F) was brown eyed. This man and woman have a blue eyed child (G) what are the genotypes of all the individuals mentioned? ( brown is dominant over blue) Could two blue eyed parents have a brown eyed child? Could two brown eyed parents have a blue eyed child?
Attached are three pedigrees. For each trait, considerwhether it is or is not consistent with X-linked recessiveinheritance. In a sentence or two, indicate why or why not.
Piebald spotting is a condition found in humans inwhich there are patches of skin that lack pigmentation. The condition results from the inability ofpigment-producing cells to migrate properly duringdevelopment. Two adults with piebald spotting haveone child who has this trait and a second child withnormal skin pigmentation.a. Is the piebald spotting trait dominant or recessive?What information led you to this answer?b. What are the genotypes of the parents?
a human disease known as cystic fibrosis is inherited as a recessive trait.Two unaffected individuals have a first child with the disease. What isthe probability that their next two children will not have the disease?
Incontinentia pigmenti, a rare, X-linked dominant disorder inhumans, is characterized by swirls of pigment in the skin. If anaffected female, who had an unaffected father, has children with anunaffected male, what are the predicted ratios of affected andunaffected sons and daughters?
.Certain forms of human color blindness are inherited as X-linkedrecessive traits. Hemizygous males are color-blind, but heterozygous females are not. However, heterozygous females sometimeshave partial color blindness.A. Discuss why heterozygous females may have partial color blindness.B. Doctors identified an unusual case in which a heterozygousfemale was color-blind in her right eye but had normal colorvision in her left eye. Explain how this might have occurred.