a often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life?  What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait? Is there one mutant copy sufficient

BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)
10th Edition
ISBN:9781305967359
Author:STARR
Publisher:STARR
Chapter30: Sensory Perception
Section: Chapter Questions
Problem 2CT
icon
Related questions
Question

Based on the figure below:

If children with hereditary retinoblastoma often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life?  What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait?

Is there one mutant copy sufficient to predispose a person to develop the cancer or two copies are needed to develop retinoblastoma as a cancer?

 

(a) Hereditary retinoblastoma
Loss of
functional
Rb allele
RB
RB
RB
RB
Somatic retinal
cell
Homozygous cell
gives rise to
tumors in retina
(b) Sporadic retinoblastoma
Loss of 1st
Loss of 2nd
functional
Rb allele
functional
Rb allele
RB
RB+
RB
RB
RB
RB
Homozygous cell
gives rise to
tumors in retina
Somatic retinal
cell
Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company
Transcribed Image Text:(a) Hereditary retinoblastoma Loss of functional Rb allele RB RB RB RB Somatic retinal cell Homozygous cell gives rise to tumors in retina (b) Sporadic retinoblastoma Loss of 1st Loss of 2nd functional Rb allele functional Rb allele RB RB+ RB RB RB RB Homozygous cell gives rise to tumors in retina Somatic retinal cell Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Mutation
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)
BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)
Biology
ISBN:
9781305967359
Author:
STARR
Publisher:
CENGAGE L
Human Physiology: From Cells to Systems (MindTap …
Human Physiology: From Cells to Systems (MindTap …
Biology
ISBN:
9781285866932
Author:
Lauralee Sherwood
Publisher:
Cengage Learning
Biology: The Unity and Diversity of Life (MindTap…
Biology: The Unity and Diversity of Life (MindTap…
Biology
ISBN:
9781337408332
Author:
Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:
Cengage Learning
Biology: The Unity and Diversity of Life (MindTap…
Biology: The Unity and Diversity of Life (MindTap…
Biology
ISBN:
9781305073951
Author:
Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:
Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:
9781305389892
Author:
Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:
Cengage Learning
Principles Of Radiographic Imaging: An Art And A …
Principles Of Radiographic Imaging: An Art And A …
Health & Nutrition
ISBN:
9781337711067
Author:
Richard R. Carlton, Arlene M. Adler, Vesna Balac
Publisher:
Cengage Learning