acetyl COA,H₂O, NAD+HSCOA, CO2,NADH/H+HCO₂CO₂a-ketoisovaleratea-ketoisocaproateLeucine is biosynthesized from a-ketoisocaproate, which is itself formed from a-ketoisovalerate by a multistep route.Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.Arrow-pushing InstructionsA-HHO: CO₂HBHCO₂CO2CO₂HH₂O: A A BH+00

Step 1: Step 2: Step 3: Step 4:

Answered: acetyl COA, H₂O, NAD+ HSCOA, CO2,…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter29: The Organic Chemistry Of Metabolic Pathways

Section29.SE: Something Extra

Problem 30MP

See similar textbooks

Similar questions

One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of xylulose 5-phosphate with ribose 5-phosphate in the presence of a transketolase to give glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. (a) The first part of the reaction is nucleophilic addition of thiamin diphosphate (TPP) ylide to xylulose 5-phosphate, followed by a retro-aldol cleavage to give glyceraldehyde 3-phosphate and a TPPcontaining enamine. Show the structure of the enamine and the mechanism by which it is formed. (b) The second part of the reaction is addition of the enamine to ribose 5-phosphate followed by loss of TPP ylide to give sedoheptulose 7-phosphate. Show the mechanism.
List the following in order of increasing tendency to accept electrons: (a) α-ketoglutarate + CO2 (yielding isocitrate); (b) oxaloacetate; (c) O2; (d) NADP+.
In one of the steps in this pathway fructose 1,6-biphosphate (F1,6BP) is converted to gylceraldehyde-3-phosphate (G-3-p) and dihydroxyacetone phosphate (DHAP). This reaction is catalyzed by the enzyme aldolase. For this reaction at 25 celcuius and Ph7 we have: Keq= 10-4M and Delta G = +5456 cal/mol Calculate the following: The concentration of F1, 6BP, DHAP and G-3-P at equilibrium when the initial F1,6BP is (A) 1M, (b) 10-2 M, (c) 2 X 10*4 M and (d) 10-5 M. I been trying to solve this problem but I dont even know where to begin with. Atleast help me with problem A, I would be able to guide myself through.
Which compound in each of the following pairs is the better reducing agent? a. NADH/H2O b. UQH2/FADH2 c. Cyt c (reduced)/cyt b (reduced) d. FADH2/NADH e. NADH/FMNH2
Which of the reactions are spontaneous (favorable)? 1)DHAP↽−−⇀glyceraldehyde-3-phosphateΔ?=3.8 kJ/mol 2)L-malate+NAD+⟶oxaloacetate+NADH+H+Δ?=29.7 kJ/mol- 3) glutamate+NAD++H2O⟶NH+4+α-ketoglutarate+NADH+H+Δ?=3.7 kcal/ 4) C6H13O9P+ATP⟶C6H14O12P2+ADPΔ?=−14.2KJ/mol 5) −Rh(I)C2H6Δ?=−150.97 kJ/molC2H4+H2→Rh(I)C2H6ΔG=−150.97 kJ/mol 6) C4H4O5⟶C4H2O4+H2OΔ?=3.1 kJ/mol
using the list of reagents provided which are needed to turn the following into butanoic acid?a) Butanalb) 1-chlorobutaneplease arrange the order of letters from left to right i.e. af = CrO3 / H3O+, NaOH
The vitamin Niacin is used to form nicotinamide adenosine dinucleotide, which readily shuttles between its oxidized (NAD+) and reduced (NADH) forms. The latter serves as a cellular equivalent to NaBH4. The essential portions of the structures are shown below. Outline a mechanism for the cellular conversion of pyruvate to lactate. (Note: like NaBH4, NADH cannot reduce carboxylic acid carbonyls).
High concentration of glucose 6-phosphate is inhibitory to ____. (I) Hexokinase (II) Pyruvate kinase (III) Glucokinase(IV) Phosphofructoskinase-1 Select one: a. (I) only b. (I) and (III) only c. (III) only d. (III) and (IV) only
One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of sedoheptulose 7-phosphate with glyceraldehydes 3-phosphate in the presence of a transaldolase to yield erythrose 4-phosphate and fructose 6-phosphate. (a) The first part of the reaction is the formation of a protonated Schiff base of sedoheptulose 7-phosphate with a lysine residue in the enzyme followed by a retro-aldol cleavage to give an enamine plus erythrose 4-phosphate. Show the structure of the enamine and the mechanism by which it is formed. (b) The second part of the reaction is a nucleophilic addition of the enamine to glyceraldehyde 3-phosphate followed by hydrolysis of the Schiff base to give fructose 6-phosphate. Show the mechanism.
In step 7 of fatty-acid biosynthesis (Figure 29-5), dehydration of a -hydroxy thioester occurs to give trans-crotonyl ACP. Is the dehydration a syn elimination or an anti elimination?
In glycerol metabolism, the oxidation of sn-glycerol 3-phosphate to give dihydroxyacetone phosphate is catalyzed by sn-glycerol-3-phosphate dehydrogenase, with NAD+ as cofactor. The reaction is stereospecific, occurring exclusively on the Re face of the nicotinamide ring.
Draw the products that form when the thioester CH3CH2CH2COSCoA is hydrolyzed with water. Differentiate products by greater or lesser molecular weight.

SEE MORE QUESTIONS

Recommended textbooks for you

Organic Chemistry

Chemistry

ISBN:

9781305080485

Author:

John E. McMurry

Publisher:

Cengage Learning

Pushing Electrons

Chemistry

ISBN:

9781133951889

Author:

Weeks, Daniel P.

Publisher:

Cengage Learning

Organic And Biological Chemistry

Chemistry

ISBN:

9781305081079

Author:

STOKER, H. Stephen (howard Stephen)

Publisher:

Cengage Learning,

Organic Chemistry

Chemistry

ISBN:

9781305080485

Author:

John E. McMurry

Publisher:

Cengage Learning

Pushing Electrons

Chemistry

ISBN:

9781133951889

Author:

Weeks, Daniel P.

Publisher:

Cengage Learning

Organic And Biological Chemistry

Chemistry

ISBN:

9781305081079

Author:

STOKER, H. Stephen (howard Stephen)

Publisher:

Cengage Learning,

General, Organic, and Biological Chemistry

Chemistry

ISBN:

9781285853918

Author:

H. Stephen Stoker

Publisher:

Cengage Learning

Introduction to General, Organic and Biochemistry

Chemistry

ISBN:

9781285869759

Author:

Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:

Cengage Learning

SEE MORE TEXTBOOKS