Give good hand written explanation of both question. Asapthank you After 16 hours of fasting, your braincells need energy and since brainuses glucose as a major source ofenergy - your body can synthesize itby lipolysisTrueFalseAll inhibitors of eicosanoids act byinhibiting the cyclooxygenasesTrueFalse(

Eicosanoids are oxidized derivatives of 20-carbon polyunsaturated fatty acids (PUFAs). The…

Answered: After 16 hours of fasting, your brain…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 7P

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GTP or ATP is produced during the conversion of isocitrate into ketoglutarate succinyl CoA into succinate fumarate into malate malate into oxaloacetate
Understanding the Mechanisms of Reactions Related to Transketolase The mechanistic chemistry of the acetolactate synthase and phosphoketolase reactions (shown here) is similar to that of the transketolase reaction (Figure 22.30). Write suitable mechanisms for these reactions.
Radiolabeling with 14C-Glutamate Describe the labeling pattern that would result from the introduction into the TCA cycle of glutamate labeled at Cy with 14C.
Acetyl CoA can be converted to all of the following except ________. ketone bodies fatty acids polysaccharides triglycerides
Years ago there was interest in using uncouplers such as dinitrophenol asweight control agents. Presumably, fat could be oxidized without concomitant ATP synthesis for re-formation of fat or carbohydrate. Why was this a bad (i.e., fatal) idea?
When the production of acetyl-CoA exceeds the body’scapacity to oxidize it, acetoacetate, b-hydroxybutyrate, andacetone accumulate. When generated in large amounts, thesesubstances can exceed the blood’s buffering capacity. As theblood pH falls, the ability of red blood cells to carry oxygen isaffected. Subsequently, the brain can be starved for oxygen,and a fatal coma can result. Explain how severe dieting canproduce this condition.
Coenzyme Q (CoQ) is sold as a nutritionalsupplement. One company uses this marketing slogan for CoQ: “Give your heart thefuel it craves most.” Considering the role ofcoenzyme Q, critique this claim. How do youthink this product might function to benefitthe heart? Is CoQ used as a “fuel” during cellular respiration?
3. β-oxidation of higher fatty acids:3.1. tissue and intracellular localization of the process3.2. activation of fatty acids3.3. mechanism of fatty acids transport to mitochondria with theparticipation of carnitine
Pyruvate dehydrogenase catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, one molecule each of the catalytic coenzymes TPP, FAD and lipoamide participate in the reaction but are not consumed. OTrue O False
Fatty acids are oxidized by acyl COA dehydrogenase. Branched fatty acids, containing a methyl group at beta carbons cannot be oxidized by this enzyme. How does the oxidation of such branched fatty acids take place? Explain with all set of reactions and enzymes involved.. give necessary detail.. avoid cpy righting
Glycerol generated from TG hydrolysis in adipocytes is converted by the liver into _________________________, whichserves as a substrate for the synthesis of glucose, amongother molecules
Urea formation is energetically expensive, requiring theexpenditure of 4 mol of ATP per mole of urea formed.However, NADH is produced when fumarate is reconvertedto aspartate. How many ATP molecules are produced bythe mitochondrial oxidation of the NADH? What is the netATP requirement for urea synthesis?

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After 16 hours of fasting, your brain cells need energy and since brain uses glucose as a major source of energy - your body can synthesize it by lipolysis O True O False All inhibitors of eicosanoids act by inhibiting the cyclooxygenases O True O False