Alternative pathway Lectin pathway Classical pathway Triggered by Triggered by Triggered by Mannose-binding lectin (MBL) binding to microbial invaders C3b binding to microbial invaders Antibodies binding to microbial invaders - Antibody C3b MBL YY Formation of C3 convertase C3 Splits C3 Opsonization C3b binds to microbial cells, functioning as an opsonin. Inflammatory response C3a and C5a induce changes that contribute to local vascular permeability and attract phagocytes. C3a C3b C3b Combines with C3 convertase to form an C5 enzyme that splits C5 C5a C5b FIGURE 14.11 Complement System The three pathways of complement system activation converge, leading to the same three outcomes (the inflammatory C5b Lysis of foreign cells C5b combines with complement proteins C6, C7, C8, and C9 to form membrane attack complexes that insert into cell membranes. response, lysis of foreign cells, opsonization). Not all of the steps in these pathways are shown.

Alternative pathway Lectin pathway Classical pathway Triggered by Triggered by Triggered by Mannose-binding lectin (MBL) binding to microbial invaders C3b binding to microbial invaders Antibodies binding to microbial invaders - Antibody C3b MBL YY Formation of C3 convertase C3 Splits C3 Opsonization C3b binds to microbial cells, functioning as an opsonin. Inflammatory response C3a and C5a induce changes that contribute to local vascular permeability and attract phagocytes. C3a C3b C3b Combines with C3 convertase to form an C5 enzyme that splits C5 C5a C5b FIGURE 14.11 Complement System The three pathways of complement system activation converge, leading to the same three outcomes (the inflammatory C5b Lysis of foreign cells C5b combines with complement proteins C6, C7, C8, and C9 to form membrane attack complexes that insert into cell membranes. response, lysis of foreign cells, opsonization). Not all of the steps in these pathways are shown.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 11QP: It is often helpful to draw a complicated pathway in the form of a flow chart to visualize the...

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