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- Which of the following is correct? A. The gene CYP21A2 is the one that codes for the formation of glucose-6 phosphate dehydrogenase B. Simple virilizing form of Congenital adrenal hyperplasia is the most sever form of this disorder C. Salt wasting type of congenita adrenal hyperplasia is the most severe form of this disorder. D. The gene CYP21A1 is the one that codes for the formation of galactokinase in type 2 galactosemia.which of the following are possible sources of glyceraldehyde 3-phosphate a. more than 1 correct response b. 2 moles of glucos c. cleavage of fructose-1-6-biphosphate d. dihydroxyacetone phosphateAll of the following are true with respect to alpha-glucosidase inhibitor, except:A. It inhibits intestinal alpha-glucosidase B. It decreases enzymatic conversion of oligo- to monosaccharidesC. It lowers postprandial glucoseD. It causes gastrointestinal disturbances.E. It may cause development of hypertension.
- Match the each enzyme deficiency with their corresponding disease β-hexosaminidase A α -galactosidase Sphigomyelinase β-glucosidase A. Fabry disease B. Tay-Sachs disease C. Niemann-Pick disease D. Gaucher diseaseHbA1c is used to monitor blood glucose levels because hemoglobin is the only protein in blood that is covalently modified by glucose. True False Insulin Glargine is a long-acting form of insulin that is synthesized with several D-amino acids that slow its proteolytic degradation and extend the half-life of the insulin Glargine molecule. True FalseA 9 year old mentally retarded girl with a protuberant abdomen, short stature, coarse facial features and cloudy corneas. skeletal malformations include dysostosis Multiplex and Bullet shaped middle phalanx .what is the enzyme deficient in this patient? A)Iduronate sulfatase B) beta - Galactosidase C)alpha - L- Iduronidase D) beta - Glucuronidase
- Describe one mechanism that leads to continued gluconeogenesis in the liver of T1DM patients, despite already high levels of glucose in the bloodstream.The following diagram shows the biosynthesis of B12 coenzymes, starting with the vitamin. DMB is dimethylbenzimidazole. (a) What one additional substrate or cofactor is required by enzyme B?(b) Genetic deficiency in animals of enzyme C would result in excessiveurinary excretion of what compound?(c) Some forms of the condition described in (b) can be successfully treatedby injection of rather massive doses of vitamin B12. What kind ofgenetic alteration in the enzyme would be consistent with this result?(d) Genetic deficiency in animals of enzyme B will result in excessive urinaryexcretion of what amino acid?explain whether lactase enzyme is secreted as a zymogen requiring activation or not. If it is, please name the secreted zymogen, and explain how and where it is activated.
- Which of the following statements for McArdle’s Disease is NOT correct? a. It is an inherited disorder. b. Patients have high quantities of glycogen in muscles, implying that glycogen synthesis is normal. c. Patients have no glycogen phosphorylase activity and thus no glycogen breakdown. d. Patients have high concentration of blood glucose, implying that glucose synthesis is normal.Answer the following using the picture attached: A. How does pepsin differ from chymotrypsin in terms of its active site residues and mechanism? B. How do these changes permit pepsin to operate at such a low pH?If glucagon binds to the liver cell, what is the expected regulation of the bifunctional enzyme phosphofructokinase-2/fructose-2,6-bisphosphatase and how would the levels of fructose-2,6-bisphosphate be impacted?