Describe one mechanism that leads to continued gluconeogenesis in the liver of T1DM patients, despite already high levels of glucose in the bloodstream.
Q: Describe the genetics of lactose tolerance/intolerance,
A: Lactose intolerance means an individual is unable to properly digest the lactose. It means lactose…
Q: Which weight loss suggestion is designed to achieve some level of ketosis? Atkins Diet Exercise…
A: Ketosis is a metabolic condition that occurs naturally. It entails the body generating ketone bodies…
Q: Name three enzymes and/or genes that you will evaluate in order to verify increased de novo…
A: Lipogenesis is a metabolic pathway in which conversion of acetyl CoA to triglycerides happen. It…
Q: Which TCA component is syphoned off to increase glucose production via gluconeogenesis when glucose…
A: Glucogenesis is a metabolic pathway that results in the generation of glucose. It is an important…
Q: Can the intake of alanine, glycine, and serine relieve hypoglycemia caused by starvation? Explain.
A: Hypoglycemia- When the blood glucose level is less than normal level of glucose the condition result…
Q: (human physiology) 1) Match the insulin types (1-3) with the plots (A-C)? Explain? 2) Oral…
A: Insulins are polypeptides which undergo minor transformations to become active in the body and are…
Q: Alpha-glucosidase inhibitors are contraindicated in all of the following cases, except:A. Diabetic…
A: Alpha glucosidase inhibitors are generally used in the treatment of type-II diabetes. Alpha…
Q: What controls whether PFK2 or FBPase2 dominates the bifunctional enzyme’s activities in the liver?
A: Phosphofructokinase is an enzyme that catalyzes the step of glycolysis as well as gluconeogenesis.…
Q: What are the advantages of intravenous infusion of glucose than other injection like subcutaneous…
A: Routes of drug administration is the path by which the drugs, fluids or other medicines are…
Q: Why are SGLT1 inhibitors drugs able to lower blood glucose and why do they cause diarrhea?
A: SGLT1 stands for sodium glucose cotransport 1.
Q: Suggest another mutation in glucose metabolism that causes symptoms similar to those of von Gierke…
A: Glycogen storage disease 1 is caused due to the absence of the glucose-6-phosphatase enzyme which…
Q: Certain malignant tumors of the pancreas cause excessive production of insulin. Affected individuals…
A: The pancreas is the organ located at the abdomen. It is part of the digestive system as well as the…
Q: Fructose 1,6-bisphosphatase is the principal enzyme controlling the rate of gluconeogenesis and is…
A: Fructose 1,6-bisphosphate is an enzyme that is responsible for the conversion of…
Q: Many patients with glucose 6- phosphatase deficiency have high serum levels of urate. Hyperuricemia…
A: Many patients with glucose 6-phosphate deficiency have high serum levels of urate. Hyperuricemia can…
Q: In many individuals with severe cases of A1AT deficiency (the ZZ genotype), intracellular…
A: Alpha-1-Antitrypsin deficiency (AATD) is a genetically inherited autosomal-codominant or autosomal…
Q: A 9 year old child was brought to the clinic with a history of failure to thrive. Further…
A: In the given question, child presents with failure to thrive, generalized hypotonia, hepatomegaly…
Q: In the liver, the relative activity of ornithine transcarbamylase is high, that of argininosuccinate…
A: Ornithine transcarbamylase is the enzyme that catalyzes the conversion of carbamyl phosphate and…
Q: Name the glycolytic enzymes that are allostericallyregulated.
A: Glycolysis is the cytoplasmic pathway which breaks down glucose into two three-carbon compounds and…
Q: Differentiate glycogenolysis and glycogenesis Compare and contrast embden mayerhof pathway and…
A: Glucose is the most important source of energy. For metabolic reactions such as cellular…
Q: How is Pyruvate Kinase Deficiency (PKD) inherited? What gene is responsible for the expression of…
A: Pyruvate kinase is an enzyme that regulates cell metabolism by catalysing the conversion of…
Q: Phosphorylation of CFTR by ____________ results in Cl− and HCO-3 secretion into the intestinal…
A: CFTR belongs to the ATP-binding cassette (ABC) transporter superfamily. It helps to maintain the…
Q: Glycogen synthesis and breakdown are regulated primarily at the hormonal level. However, important…
A: The glycogen is polysaccharide the glucose molecules, which are a multi branched chain. The glycogen…
Q: As less glucose is available due to a low carb diet what happens to the ability of the TCA cycle to…
A: Glucose is the first molecule that is responsible for the process of cellular respiration. It is…
Q: In people with diabetes mellitus Type 1, explain the reason for:(a) ketoacidosis, and (b) ketonuria.
A: The condition in which the blood has high glucose level is called diabetes or diabetic mellitus.…
Q: In 3-4 sentences, briefly explain how lactate is formed, the biological effect of lactate, and…
A: NOTE: As per our honor code, we are allowed to answer only one question at a time. Since you have…
Q: explain why natural protease inhibitors (peptide extracts from the pancreas of cattle - aprotinin)…
A: Enzymes are known as biological catalysts. The function of a catalyst is to accelerate the rate of a…
Q: What pathway in addition to the cAMP-induced signal transduction pathway is used in the liver to…
A: Glycogen breakdown occurs when the body is in need of glucose to produce energy in the form of ATP.…
Q: Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations…
A: GLUT 4 is a type of glucose transporter. GLUT 4 transports glucose only when insulin is present.…
Q: Elevated concentration of blood ketones is referred to as _____________.
A: Ketone bodies are the water-soluble molecules containing the keone group that is produced by the…
Q: The symptoms of partial deficiency of a urea cycle enzyme may be minimized by a low- protein diet.…
A: Urea-cycle disorder is a genetic disorder that affects the breakdown of proteins in the body. The…
Q: Give details of secondary structure of Mature Bovine insulin
A: In the pancreatic beta cells, bovine insulin is produced it is a two-chain polypeptide…
Q: All of the following are true with respect to alpha-glucosidase inhibitor, except:A. It inhibits…
A: Diabetes type 2 is adult-onset diabetes and is identified by a high level of sugar in the blood,…
Q: In the intestine, the triacylglycerols must be converted to fatty acids and glycerol by hydrolytic…
A: Triglycerides (TAGs) are made from glycerol and three fatty acids (same or different). It is the…
Q: Suggest the effects of each of the following mutations on the physiologicalrole of…
A: The chymotrypsinogen is inactive enzyme and is also known as zymogen. This is a proenyzme which…
Q: What metabolic and hormonal changes account for decreased gluconeogenesis during the first several…
A: Gluconeogenesis: Metabolic pathway that produces glucose through non-carbohydrate carbon…
Q: describe the development of lactose intolerance from child age to adult age. also describe the…
A: Lactose intolerance means that you are unable to fully digest the lactose milk. For people with…
Q: 21. Explain how the activation of acetyl-CoA carboxylase is the appropriate response to insulin…
A: Since you have asked multiple questions, we will solve the first question for you. If you want any…
Q: explain whether lactase enzyme is secreted as a zymogen requiring activation or not. If it is,…
A: The lactase enzyme is a beta-galactosidase that hydrolyses lactose to glucose and galactose. A…
Q: Discuss the central role of glutamate in nitrogen metabolism in both muscle and the liver.
A: Many of the α-amino acids' amino groups are accumulated in the liver as the amino group of…
Q: a. Outline and describe the reaction scheme of the production of glucose from maltodextrin by using…
A: Enzymes are highly specialized proteins that have extraordinary catalytic power, greater than that…
Q: Which of the following is NOT an effect of folate deficiency?
A: Folic acid is also called vitamin B9 and it is a water-soluble vitamin. Folic acid is also…
Q: The following is a typical underlying factor in obesity-induced inflammation a) Increased…
A: Introduction Obesity is defined as being significantly overweight for one's height, compromising…
Q: Explain the effects of each of the following on gluconeogenesis and glycolysis in a liver cell. Mark…
A: There are enzymes and factor which promotes glucose synthesis and when energy required it promotes…
Describe one mechanism that leads to continued gluconeogenesis in the liver of T1DM patients, despite already high levels of glucose in the bloodstream.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- In many individuals with severe cases of A1AT deficiency (the ZZ genotype), intracellular accumulations in the liver are usually noted upon biopsy. What might be the cause of this phenomenon?Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations are important in the response of muscle,adipose tissue, brain, and liver to insulinexplain why natural protease inhibitors (peptide extracts from the pancreas of cattle - aprotinin) can also arrest the destruction of pancreatic proteins, but often cause an allergic reaction.
- HbA1c is used to monitor blood glucose levels because hemoglobin is the only protein in blood that is covalently modified by glucose. True False Insulin Glargine is a long-acting form of insulin that is synthesized with several D-amino acids that slow its proteolytic degradation and extend the half-life of the insulin Glargine molecule. True FalseExplain how excessive ketone bodies may form in the following: During starvation In patients with diabetes mellitusExplain the rationale for the production of ketone bodies during starvation.
- All of the following are true with respect to alpha-glucosidase inhibitor, except:A. It inhibits intestinal alpha-glucosidase B. It decreases enzymatic conversion of oligo- to monosaccharidesC. It lowers postprandial glucoseD. It causes gastrointestinal disturbances.E. It may cause development of hypertension.It has been suggested that a high-sugar diet may lead to non-alcoholic fatty liver disease. Explain?Why are leptin injections less helpful for most overweight people than for mice with the obese gene?
- List the seven metabolites that represent the end products of amino acid catabolism. Which are glucogenic? Which are ketogenic?BRIEFLY EXPLANATION: How heart issues, hypertension and highly fat diet can lead to diabetic ketoacidosis?Administration of insulin decreases the blood concentration of ketone bodies in patients with diabetic ketoacidosis by which of the following mechanisms?A) Decreasing formation of ketone bodies in skeletal muscleB) Decreasing lipolysis in adipose tissueC) Increasing hepatic activity of carnitine acyltransferaseD) Increasing hepatic levels of acetyl CoAE) Increasing hepatic oxidation of ketone bodies