The Turner Kieser Syndrome (or nail patella syndrome) is a dominant human disease (prevalenceabout 1/100.000), which impairs the normal development of, nails and kneecaps (patella). In thefollowing study the mutant allele for this gene is noted "M" and the wild type allele "m".On the family tree below black symbols (circles for women and squares for men) indicate peoplesuffering from KSS and open symbols represent healthy persons. Moreover, all individuals have beengenotyped at the locus controlling blood type ([O] : ii ; [A] : Iª_ ; [B] : /B_ ; [AB] : /A/B)12Reminder3ilB iIB23OiIB IB iIB7Oii iIB IB IA ii iiZ(0) = Log1064What to conclude from this value of Z ?5ilA ilAii89probability if linkageprobability if independant102ilBCalculate the LOD-score Z (Logarithm Of Odds) for a genetic distance set to 10 cM (hence arecombination frequency of 0 = 0,1).11 12 13=ii iIB ii ii ii iIB IB14 15 16Log10L (0<0,5)L (0=0,5)

One or more X chromosomes may be completely or partially absent in females with Turner syndrome, a…

Calculate the LOD-score Z (Logarithm Of Odds) for a genetic distance set to 10 cM (hence a recombination frequency of 0 = = 0,1). Reminder Z(0) = Log10 probability if linkage probability if independant What to conclude from this value of Z? = Log10 L (0<0,5) L (0=0,5)

Calculate the LOD-score Z (Logarithm Of Odds) for a genetic distance set to 10 cM (hence a recombination frequency of 0 = = 0,1). Reminder Z(0) = Log10 probability if linkage probability if independant What to conclude from this value of Z? = Log10 L (0<0,5) L (0=0,5)

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter19: Introduction To Genetics

Section: Chapter Questions

Problem 4CT: The young woman shown at right has albinismvery pale skin, white hair, and pale blue eyes. This...

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Question

The Turner Kieser Syndrome (or nail patella syndrome) is a dominant human disease (prevalence
about 1/100.000), which impairs the normal development of, nails and kneecaps (patella). In the
following study the mutant allele for this gene is noted "M" and the wild type allele "m".
On the family tree below black symbols (circles for women and squares for men) indicate people
suffering from KSS and open symbols represent healthy persons. Moreover, all individuals have been
genotyped at the locus controlling blood type ([O] : ii ; [A] : Iª_ ; [B] : /B_ ; [AB] : /A/B)
1
2
Reminder
3
ilB iIB
2
3
O
iIB IB iIB
7
O
ii iIB IB IA ii ii
Z(0) = Log10
6
4
What to conclude from this value of Z ?
5
ilA ilA
ii
8
9
probability if linkage
probability if independant
10
2
ilB
Calculate the LOD-score Z (Logarithm Of Odds) for a genetic distance set to 10 cM (hence a
recombination frequency of 0 = 0,1).
11 12 13
=
ii iIB ii ii ii iIB IB
14 15 16
Log10
L (0<0,5)
L (0=0,5)

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