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Name: Capacity to carry oxygen by sickle cell hemoglobin is reduced due to A
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Description: Capacity to carry oxygen by sickle cell hemoglobin is reduced due to A premature termination of a- globin chain translationb splice junction mutationc formation of a rope-like polymer of deoxyhemoglobind Micro RNA expression in hematopoietic celles E

Science

Biology

Capacity to carry oxygen by sickle cell hemoglobin is reduced due to

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 12P

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Which statement is false: A) Each type of protein ( ex: hemoglobin vs trypsionngen) varies in the length and amino acid sequence of its peptide B) After the rpocess of transcription is complete, the mRNA that is produced will continue being tranlsated by ribosomes for the rest of the cells life. mRNA never breaks down C) A ribosome will bind to an mRNA and will translate the sequence by reading one codon at a time and adding one amino acid to the peptide chain. It will stop the translation once it encounters a stop codon D) The gene for a protein provides the information on the legth of the peptide, along w the amino acid sequence so the protein can be synthesized by a ribosome E) Once mRNA has left the nucleus, ribosomes will bind to it and will follow the instructions in its sequence to make the new protien
the difference in primary structure between related tropomyosin informs arises from a) alternative splicing b) C-to-U editing c) farnesylation d) H3K4 methylation e) targetting to secretory vesicles
Label each true or false A.STTGATA3 is the consensus sequence of the -35 regulatory region of prokaryotic genes B. The chromosomes in the image to the right illustrate a reciprocal translocation: (picture) C. When histones are deacetylated, nucleosomes transcription is repressed.
Please answer the following questions, no need to explain each choices just explain the correct answer. 1. Which of the following has only one equivalent codon? A) Ala B) Arg C) Val D) Trp E) Gly 2. Which of the following does not describe transcription? A) Synthesis of RNA using DNA as the template B) Requires DNA-dependent RNA Pol C) Highly selective process that is strictly regulated D) A step in gene expression E) None of the above
RNAi: a) is a cellular defense system against viral replication b) involves dicer recognition of single stranded RNAs c) relies on a dicer/RNA complex to 'find' matching RNA d) functions post-translationally to decrease gene expression e) A, B and C
Histone deacetylase (HDAC) enzymes a.Promote initiation of translation. b.Complex with hyperphosphorylated pRb. c.Repress E2F family activity. d.Add acetyl groups to E2F promoters. e.Promote initiation of transcription.
A scientist mutates eIF-2 to eliminate its GTP hydrolysis capability. How would this mutated form of eIF-2 alter translation? a. Initiation factors would not be able to bind to mRNA. b. The large ribosomal subunit would not be able to interact with mRNA transcripts. c. tRNAi-Met would not scan mRNA transcripts for the start codon. d. eIF-2 would not be able to interact with the small ribosomal subunit.
Mutations in the IL2RG gene cause approximately 30 percent of severe combined immunodeficiency disorder (SCID) cases in humans. These mutations result in alterations to a protein component of cytokine receptors that are essential for proper development of the immune system. The IL2RG gene is composed of eight exons and contains upstream and downstream sequences that are necessary for proper transcription and translation. Below are some of the mutations observed. For each, explain its likely influence on the IL2RG gene product (assume its length to be 375 amino acids). (a) Nonsense mutation in a coding region (b) Insertion in Exon 1, causing frameshift (c) Insertion in Exon 7, causing frameshift (d) Missense mutation (e) Deletion in Exon 2, causing frameshift (f) Deletion in Exon 2, in frame (g) Large deletion covering Exons 2 and 3
Formation of the 70S ribosomal initiation complex for prokaryotic translation requires A. Mn2+ B. EF-Tu C. tRNAMet D. tRNAfMet D. IF-2 E. GTP
Another thalassemic patient had a mutation leading to the production of an mRNA for the β chain of hemoglobin that was 900 nucleotides longer than the normal one. The poly(A) tail of this mutant mRNA was located a few nucleotides after the only AAUAAA sequence in the additional sequence. Propose a mutation that would lead to the production of this altered mRNA.
EF-Ts factor regenerates EF-Tu/GDP from EF-Tu/GTP for the next round of elongation cycle in prokaryotic translation. The sigma subunit of RNA polymerase is replaced by NusA to recognise the promoter region of a gene. The -10 and -35 sequences in E. coli DNA are referred to as untranslated region. In human, translation begins before transcription of an mRNA completes. this statement true or false.
he bands indicated by arrow "A" (to the left of the western blot) most likely represent: A. PX-HA lacking any post-translational modifications. B. dephosphorylated PX-HA. C. phosphorylated PX-HA. D. PX-HA with its N-terminal signal sequence still attached. E. glycosylated PX-HA.